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Semiparametric efficient estimation of small genetic effects in large-scale population cohorts.

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第一作者： Olivier,Labayle

第一单位： School of Informatics, University of Edinburgh, 10 Crichton Street, Edinburgh EH8 9AB, United Kingdom.;Institute for Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, United Kingdom.

作者： Olivier,Labayle ^[1] ; Breeshey,Roskams-Hieter ^[2] ; Joshua,Slaughter ^[3] ; Kelsey,Tetley-Campbell ^[4] ; Mark J,van der Laan ^[5] ; Chris P,Ponting ^[4] ; Sjoerd V,Beentjes ^[6] ; Ava,Khamseh ^[7]

作者单位： School of Informatics, University of Edinburgh, 10 Crichton Street, Edinburgh EH8 9AB, United Kingdom.;Institute for Regeneration and Repair, University of Edinburgh, 4-5 Little France Drive, Edinburgh EH16 4UU, United Kingdom. ^[1] Health Data Research UK, 215 Euston Road, London NW1 2BE, United Kingdom.;MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, United Kingdom. ^[2] School of Informatics, University of Edinburgh, 10 Crichton Street, Edinburgh EH8 9AB, United Kingdom. ^[3] MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, United Kingdom. ^[4] School of Public Health, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA 94720, United States. ^[5] MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, United Kingdom.;School of Public Health, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA 94720, United States.;School of Mathematics and Maxwell Institute for Mathematical Sciences, University of Edinburgh, Peter Guthrie Tait Road, Edinburgh EH9 3FD, United Kingdom. ^[6] School of Informatics, University of Edinburgh, 10 Crichton Street, Edinburgh EH8 9AB, United Kingdom.;MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Crewe Road South, Edinburgh EH4 2XU, United Kingdom.;School of Public Health, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA 94720, United States. ^[7]

关键词 bioinformatics non-parametric methods statistical genetics statistical methods in epidemiology

医学主题词人类(Humans);遗传学, 群体(Genetics, Population);模型, 统计学(Models, Statistical);队列研究(Cohort Studies);计算机模拟(Computer Simulation);模型, 遗传学(Models, Genetic);生物统计学(Biostatistics)

DOI 10.1093/biostatistics/kxaf030

PMID 41024427

发布时间 2026-03-26

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