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Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial.

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第一作者： Filip K,Knop

第一单位： Novo Nordisk, Søborg, Denmark. Electronic address: fikk@novonordisk.com.

作者： Filip K,Knop ^[1] ; George,Kunos ^[2] ; Dror,Dicker ^[3] ; Jean-Sebastien,Paquette ^[4] ; Louis,Aronne ^[5] ; Ofir,Frenkel ^[6] ; Thomas,Holst-Hansen ^[6] ; Karine,Lalonde ^[7] ; Jisoo,Lee ^[6] ; Glenn,Crater ^[7] ; trial investigators

作者单位： Novo Nordisk, Søborg, Denmark. Electronic address: fikk@novonordisk.com. ^[1] Laboratory of Physiologic Studies, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health, Bethesda, MD, USA. ^[2] Internal Medicine Department D and Obesity Clinic, Hasharon Hospital-Rabin Medical Center, Petach-Tikva, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. ^[3] Laboratoire de Recherche et d'Innovation en Médecine de Première Ligne (ARIMED), Groupe de Médecine de Famille Universitaire de Saint-Charles-Borromée, CISSS Lanaudière, Saint-Charles-Borromée, QC, Canada; VITAM Research Centre for Sustainable Health, Quebec City, QC, Canada; Department of Family Medicine and Emergency Medicine, Faculty of Medicine, Université Laval, Quebec City, QC, Canada. ^[4] Comprehensive Weight Control Center, Weill Cornell Medicine, New York, NY, USA. ^[5] Novo Nordisk, Søborg, Denmark. ^[6] Inversago Pharma, Montreal, QC, Canada. ^[7]

医学主题词成年人(Adult);老年人(Aged);女(雌)性(Female);人类(Humans);男(雄)性(Male);中年人(Middle Aged);减肥药(Anti-Obesity Agents);双盲法(Double-Blind Method);肥胖症(Obesity);哌啶类(Piperidines);吡唑类(Pyrazoles);治疗结果(Treatment Outcome);体重减轻(Weight Loss);药物, 临床试用(Drugs, Investigational)

DOI 10.1016/S2213-8587(25)00216-5

PMID 41038215

发布时间 2025-11-25

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The lancet. Diabetes & endocrinology

2025年13卷11期

911-923页

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The lancet. Diabetes & endocrinology

2025年13卷11期

911-923页

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Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial.

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Efficacy and safety of monlunabant in adults with obesity and metabolic syndrome: a double-blind, randomised, placebo-controlled, phase 2a trial.

The lancet. Diabetes & endocrinology

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