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Reversal of ACLF and ALF using whole blood extracorporeal system combining HLA-depleted liver organoids with granulocyte-monocyte apheresis.

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第一作者: Hitomi,Yamaguchi
第一单位: Department of Organogenesis and Neogenesis, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan.
作者单位: Department of Organogenesis and Neogenesis, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. [1] Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Department of Stem Cell and Organoid Medicine, Graduate School of Medicine, The University of Osaka, Suita, Osaka 565-0871, Japan. [2] Department of Organogenesis and Neogenesis, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Department of Gastroenterological Surgery I, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita-ku, Sapporo, 060-8638, Japan. [3] Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. [4] Department of Stem Cell and Organoid Medicine, Graduate School of Medicine, The University of Osaka, Suita, Osaka 565-0871, Japan. [5] Kanzo Biomedicines, Inc., 470 Noor Avenue, Ste B#1114, South San Francisco, CA 94080, USA. [6] Department of Organogenesis and Neogenesis, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Human Biology Research Unit, Institute of Integrated Research, Institute of Science Tokyo (Science Tokyo), 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan; Department of Stem Cell and Organoid Medicine, Graduate School of Medicine, The University of Osaka, Suita, Osaka 565-0871, Japan; Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka, Suita, Osaka 565-0871, Japan; Division of Gastroenterology, Hepatology and Nutrition & Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA; Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. Electronic address: Takanori.Takebe@cchmc.org. [7]
DOI 10.1016/j.jhep.2025.08.038
PMID 41044028
发布时间 2026-01-19
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Journal of hepatology

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