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In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation therapy.

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第一作者： Anna,Kirstein

第一单位： Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.

作者： Anna,Kirstein ^[1] ; Dan,Ionascu ^[2] ; Michael A S,Lamba ^[2] ; Bianca M,Ruffolo ^[1] ; Katherine J,Crail ^[1] ; Anthony E,Mascia ^[3] ; Mathieu G,Sertorio ^[2] ; Benjamin H,Hinrichs ^[4] ; Chad,Zender ^[5] ; Maria A,Lehn ^[6] ; Trisha M,Wise-Draper ^[6] ; John P,Perentesis ^[1] ; Yi,Zheng ^[1] ; Susanne I,Wells ^[1]

作者单位： Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. ^[1] Department of Radiation Oncology, College of Medicine, University of Cincinnati, Cincinnati OH 45219, USA. ^[2] Cancer and Blood Diseases Institute, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.;Department of Radiation Oncology, College of Medicine, University of Cincinnati, Cincinnati OH 45219, USA. ^[3] Department of Pathology & Laboratory Medicine, University of Cincinnati, Cincinnati, OH 45219, USA. ^[4] Department of Otolaryngology-Head and Neck Surgery, University of Cincinnati, Cincinnati, OH 45219, USA. ^[5] Department of Internal Medicine, Division of Hematology/Oncology, University of Cincinnati, College of Medicine, Cincinnati, OH 45267, USA. ^[6]

关键词 Head and Neck Squamous Cell Carcinoma (HNSCC)Proton therapy Radiation Relative biological effectiveness (RBE)X-ray radiation

DOI 10.1016/j.ctro.2025.101046

PMID 41049395

发布时间 2026-01-14

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In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation therapy.

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In vitro determination of patient-specific variation challenges the universal RBE gold standard for proton radiation therapy.

Clinical and translational radiation oncology

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Clinical and translational radiation oncology

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