首页> Journal of translational medicine> Development and validation of blood-based diagnostic biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using EpiSwitch<sup>®</sup> 3-dimensional genomic regulatory immuno-genetic profiling.

Development and validation of blood-based diagnostic biomarkers for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) using EpiSwitch<sup>®</sup> 3-dimensional genomic regulatory immuno-genetic profiling.

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第一作者： Ewan,Hunter

第一单位： Oxford BioDynamics Plc, Oxford, UK.

作者： Ewan,Hunter ^[1] ; Heba,Alshaker ^[2] ; Oliver,Bundock ^[1] ; Cicely,Weston ^[1] ; Shekinah,Bautista ^[1] ; Abel,Gebregzabhar ^[1] ; Anya,Virdi ^[1] ; Joseph,Croxford ^[1] ; Ann,Dring ^[1] ; Ryan,Powell ^[1] ; Dominik,Vugrinec ^[1] ; Caroline,Kingdon ^[3] ; Carol,Wilson ^[4] ; Sarah,Dowrick ^[4] ; Jayne,Green ^[1] ; Alexandre,Akoulitchev ^[1] ; Dmitri,Pchejetski ^[5]

作者单位： Oxford BioDynamics Plc, Oxford, UK. ^[1] Norwich Medical School, University of East Anglia, Norwich, UK. ^[2] The London School of Hygiene & Tropical Medicine, London, UK. ^[3] Royal Cornwall Hospitals NHS Trust, Truro, UK. ^[4] Norwich Medical School, University of East Anglia, Norwich, UK. d.pshezhetskiy@uea.ac.uk.;Royal Cornwall Hospitals NHS Trust, Truro, UK. d.pshezhetskiy@uea.ac.uk. ^[5]

关键词 3D-genomic profiling Autonomic dysregulation Blood test Blood-based biomarkers Chromosome conformations Chronic fatigue syndrome Diagnosis Epigenetics ME/CFS Myalgic encephalomyelitis

DOI 10.1186/s12967-025-07203-w

PMID 41057909

发布时间 2026-01-06

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