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Elucidating molecularly stratified single agent, and combination, therapeutic strategies targeting MCL1 for lethal prostate cancer.

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第一作者: Juan M,Jiménez-Vacas
第一单位: The Institute of Cancer Research, London, UK.
作者单位: The Institute of Cancer Research, London, UK. [1] The Institute of Cancer Research, London, UK.;The Royal Marsden Hospital, London, UK. [2] The Institute of Cancer Research, London, UK.;Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Department of Cell Biology, Physiology, and Immunology, University of Cordoba; Reina Sofia University Hospital; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Cordoba, Spain. [3] Divisions of Human Biology and Clinical Research, Fred Hutchinson Cancer Center, Seattle, WA, USA. [4] Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada. [5] Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. [6] Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institute of Health, Rockville, MD, USA. [7] Hematology-Oncology Division, Beth Israel Deaconess Medical Center, Boston, MA, USA. [8] Maimonides Institute for Biomedical Research of Cordoba (IMIBIC); Department of Cell Biology, Physiology, and Immunology, University of Cordoba; Reina Sofia University Hospital; CIBER Physiopathology of Obesity and Nutrition (CIBERobn), Cordoba, Spain. [9] Vancouver Prostate Centre, University of British Columbia, Vancouver, BC, Canada.;Department of Medical Pharmacology, School of Medicine, Koc University, Istanbul, Turkey. [10] Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institute of Health, Rockville, MD, USA.;Lymphoid Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA. [11] The Institute of Cancer Research, London, UK. johann.de-bono@icr.ac.uk.;The Royal Marsden Hospital, London, UK. johann.de-bono@icr.ac.uk. [12] The Institute of Cancer Research, London, UK. adam.sharp@icr.ac.uk.;The Royal Marsden Hospital, London, UK. adam.sharp@icr.ac.uk. [13]
DOI 10.1038/s41467-025-64042-5
PMID 41062500
发布时间 2025-10-09
基金项目
IES\R3\213131/Royal Society of Medicine (RSM) Challenge Award/Prostate Cancer Foundation (PCF) Clinical Research Career Development Fellowship/Wellcome Trust (Wellcome)
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