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Optimization of VE607 to generate analogs with improved neutralization activities against SARS-CoV-2 variants.

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第一作者： Shilei,Ding

第一单位： Centre de Recherche du CHUM, Montreal, Québec, Canada.

作者： Shilei,Ding ^[1] ; Derek,Yang ^[2] ; Irfan,Ullah ^[3] ; Ling,Niu ^[4] ; Matthew,Unger ^[5] ; Marco A,Díaz-Salinas ^[5] ; Monika,Chandravanshi ^[4] ; Fei,Zhou ^[6] ; Guillaume,Beaudoin-Bussières ^[7] ; Mehdi,Benlarbi ^[7] ; William D,Tolbert ^[4] ; Keon-Woong,Yoon ^[3] ; Ruixue,Xu ^[3] ; Geneviève,Laroche ^[8] ; Fleur,Gaudette ^[1] ; Abraham J,Morton ^[9] ; Zabrina C,Lang ^[9] ; Anna,Son ^[2] ; Cameron,Abrams ^[10] ; Marceline,Côté ^[8] ; Amos B,Smith ^[2] ; Rick K,Huang ^[9] ; Doreen,Matthies ^[6] ; James B,Munro ^[11] ; Marzena,Pazgier ^[4] ; Pradeep D,Uchil ^[3] ; Andrés,Finzi ^[7]

作者单位： Centre de Recherche du CHUM, Montreal, Québec, Canada. ^[1] Department of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA. ^[2] Department of Microbial Pathogenesis, Yale University, School of Medicine, New Haven, Connecticut, USA. ^[3] Infectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. ^[4] Department of Microbiology, UMass Chan Medical School, Worcester, Massachusetts, USA. ^[5] Unit on Structural Biology, Division of Basic and Translational Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, Maryland, USA. ^[6] Centre de Recherche du CHUM, Montreal, Québec, Canada.;Département de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Québec, Canada. ^[7] Department of Biochemistry, Microbiology and Immunology, Centre for Infection, Immunity and Inflammation, University of Ottawa, Ottawa, Ontario, Canada. ^[8] Laboratory of Cell Biology, National Cancer Institute, NIH, Bethesda, Maryland, USA. ^[9] Department of Chemical and Biological Engineering, Drexel University, Philadelphia, Pennsylvania, USA. ^[10] Department of Microbiology, UMass Chan Medical School, Worcester, Massachusetts, USA.;Department of Biochemistry and Molecular Biotechnology, UMass Chan Medical School, Worcester, Massachusetts, USA. ^[11]

关键词 CV3-13 K18-hACE2 transgenic mice SARS-CoV-2 VE607 cryo-EM neutralization smFRET