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Integration of Dose Surface Maps and Genetic Data Identifies the Lower Posterior Rectum as a Key Region for Toxicity after Prostate Cancer Radiotherapy.

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第一作者: Artemis,Bouzaki
第一单位: Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.
作者单位: Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom. [1] Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom.;The Christie NHS Foundation Trust, Manchester, United Kingdom. [2] Medical College of Wisconsin, Milwaukee, Wisconsin. [3] Centre of Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, United Kingdom. [4] Federation Universitaire d'Oncologie Radiothérapie d'Occitanie Méditerranée, Univ Montpellier, INSERM U1194 IRCM, Institut du Cancer Montpellier (ICM), Montpellier, France. [5] Federation Universitaire d'Oncologie Radiothérapie d'Occitanie Méditerranée, Institut du Cancer Du Gard (ICG), Nîmes, France. [6] German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany.;University Cancer Center Hamburg, University Medical Center Hamburg-Eppendorf, Heidelberg, Germany. [7] Centre for Cancer Genetic Epidemiology, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom. [8] KU Leuven, Leuven, Belgium. [9] Department of Radiation Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. [10] Department of Radiation Oncology (Maastro), Maastricht University Medical Center+, GROW School, Maastricht, Netherlands. [11] German Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg, Germany. [12] Department of Radiation Oncology, Universitätsmedizin Mannheim, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. [13] Department of Genetics & Cancer Sciences, University of Leicester, Leicester, United Kingdom. [14] Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain.;Fundación Pública Galega de Medicina Xenómica (FPGMX), Santiago de Compostela, Spain.;Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain. [15] Ghent University Hospital, Ghent, Belgium.;Ghent University, Ghent, Belgium. [16] Departments of Radiation Oncology & Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York. [17] Translational Radiobiology Group, Division of Cancer Sciences, University of Manchester, The Christie NHS Foundation Trust, Manchester, United Kingdom. [18] Data Science Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. [19]
DOI 10.1158/1078-0432.CCR-25-2102
PMID 41081635
发布时间 2025-12-03
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Clinical cancer research : an official journal of the American Association for Cancer Research

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