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Structural and molecular homogeneity of ATTRv-T60A amyloid fibrils across patients and organs.

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第一作者： Maria Del Carmen,Fernandez-Ramirez

第一单位： Center for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA.

作者： Maria Del Carmen,Fernandez-Ramirez ^[1] ; Binh A,Nguyen ^[1] ; Shumaila,Afrin ^[1] ; Virender,Singh ^[1] ; Bret,Evers ^[2] ; John M,Shelton ^[3] ; Christian Lopez,Escobar ^[3] ; Parker,Bassett ^[1] ; Lanie,Wang ^[1] ; Maja,Pękała ^[1] ; Yasmin,Ahmed ^[1] ; Luis O,Cabrera Hernandez ^[1] ; Rose,Pedretti ^[1] ; Preeti,Singh ^[1] ; Jacob,Canepa ^[4] ; Aleksandra,Wosztyl ^[4] ; Yang,Li ^[5] ; David R,Boyer ^[6] ; Qin,Cao ^[7] ; Lorena,Saelices ^[8]

作者单位： Center for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. ^[1] Department of Pathology, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA; Department of Ophthalmology, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. ^[2] Department of Pathology, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. ^[3] Graduate School of Biomedical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. ^[4] Department of Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. ^[5] Departments of Chemistry and Biochemistry and Biological Chemistry, UCLA-DOE Institute, Molecular Biology Institute, and Howard Hughes Medical Institute, UCLA, Los Angeles, CA, USA. ^[6] Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China. ^[7] Center for Alzheimer's and Neurodegenerative Diseases, Department of Biophysics, Peter O'Donnell Jr. Brain Institute, University of Texas Southwestern Medical Center (UTSW), Dallas, TX, USA. Electronic address: lorena.saelicesgomez@utsouthwestern.edu. ^[8]

关键词 ATTR Amyloids Cryoelectron microscopy amyloidosis protein aggregation seeding transthyretin