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EZHIP restricts noncanonical PRC2 binding and regulates H3K27me3 intergenerational inheritance and reprogramming.

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第一作者： Yitian,Zeng

第一单位： Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China.

作者： Yitian,Zeng ^[1] ; Feng,Kong ^[1] ; Zihan,Xu ^[1] ; Xukun,Lu ^[1] ; Qian,Li ^[1] ; Bofeng,Liu ^[1] ; Shu,Liu ^[1] ; Lijun,Dong ^[1] ; Ling,Liu ^[1] ; Wenying,Wang ^[1] ; Bing,Zhu ^[2] ; Wei,Xie ^[3]

作者单位： Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China. ^[1] National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China; Key Laboratory of Epigenetic Regulation and Intervention, Chinese Academy of Sciences, Beijing 100101, China; New Cornerstone Science Laboratory, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. ^[2] Center for Stem Cell Biology and Regenerative Medicine, MOE Key Laboratory of Bioinformatics, New Cornerstone Science Laboratory, School of Life Sciences, Tsinghua University, Beijing 100084, China; Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing 100084, China. Electronic address: xiewei121@tsinghua.edu.cn. ^[3]

关键词 EZHIP H3K27me3 Polycomb regulation early embryo epigenetic memory epigenetic reprogramming intergenerational inheritance noncanonical imprinting