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Kcnn4/KCa3.1 inhibition blunts polycystic kidney disease progression in mouse models.

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第一作者： Guanhan,Yao

第一单位： Molecular Genetics and Development, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada.

作者： Guanhan,Yao ^[1] ; Almira,Kurbegovic ^[1] ; Camila,Parrot ^[1] ; William,Foley ^[1] ; William,Roman ^[1] ; Seth L,Alper ^[2] ; Marie,Trudel ^[3]

作者单位： Molecular Genetics and Development, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada. ^[1] Division of Nephrology and Vascular Biology Research Center, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.;Department of Medicine, Harvard Medical School, Massachusetts, USA.;Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA. ^[2] Molecular Genetics and Development, Institut de recherches cliniques de Montréal, Montréal, Québec, Canada.;Department of Medicine, Department of Biochemistry and Molecular Medicine, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada. ^[3]

关键词 Drug therapy Genetic diseases Genetics Mouse models Nephrology

医学主题词动物(Animals);瞬时电导钙激活钾通道(Intermediate-Conductance Calcium-Activated Potassium Channels);小鼠(Mice);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);人类(Humans);多囊肾, 常染色体显性(Polycystic Kidney, Autosomal Dominant);男(雄)性(Male);肾(Kidney);小鼠, 基因敲除(Mice, Knockout);女(雌)性(Female);TRPP阳离子通道(TRPP Cation Channels);信号传导(Signal Transduction);钾通道阻滞剂(Potassium Channel Blockers);乙酰胺类(Acetamides)

DOI 10.1172/jci.insight.191311

PMID 41122971

发布时间 2025-11-05

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Kcnn4/KCa3.1 inhibition blunts polycystic kidney disease progression in mouse models.

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