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Identification of a novel PDE4 inhibitor inspired by leoligin-derived lignans.

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第一作者： Christine,Coffey

第一单位： Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Josef-Holaubek-Platz 2, Vienna, 1090, Austria.

作者： Christine,Coffey ^[1] ; Alexander F,Perhal ^[2] ; Wito,Richter ^[3] ; Ya,Chen ^[4] ; Thomas,Linder ^[5] ; Stefan,Schwaiger ^[6] ; Marko D,Mihovilovic ^[5] ; Johannes,Kirchmair ^[4] ; Michael,Schnürch ^[5] ; Verena M,Dirsch ^[1]

作者单位： Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Josef-Holaubek-Platz 2, Vienna, 1090, Austria. ^[1] Department of Pharmaceutical Sciences, Division of Pharmacognosy, University of Vienna, Josef-Holaubek-Platz 2, Vienna, 1090, Austria. Electronic address: alexander.perhal@univie.ac.at. ^[2] Department of Biochemistry & Molecular Biology, University of South Alabama, Frederick P. Whiddon College of Medicine, 5851 USA Drive North, Mobile, 36688, AL, USA. ^[3] Department of Pharmaceutical Sciences, Division of Pharmaceutical Chemistry, University of Vienna, Josef-Holaubek-Platz 2, Vienna, 1090, Austria. ^[4] Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/163, Vienna, 1060, Austria. ^[5] Institute of Pharmacy/Pharmacognosy, CMBI, University of Innsbruck, Innrain 80-82, Innsbruck, 6020, Austria. ^[6]

关键词 In vitro anti-inflammatory Leoligin Macrophages Natural products Phosphodiesterase 4 Structure-activity relationship cAMP