换一批Structural covariance network topology in individuals at clinical high risk for psychosis: the ENIGMA-CHR Study.
第一作者：
Siwei,Liu
第一单位：
Centre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.;Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
作者：
Siwei,Liu [1]
;
Ingrid,Agartz [2]
;
Paul,Allen [3]
;
G Paul,Amminger [4]
;
Ole A,Andreassen [5]
;
Peter,Bachman [6]
;
Inmaculada,Baeza [7]
;
Helen,Baldwin [8]
;
Cali F,Bartholomeusz [4]
;
Stefan,Borgwardt [9]
;
Sabrina,Catalano [10]
;
Xiaogang,Chen [11]
;
Kang Ik K,Cho [12]
;
Sunah,Choi [13]
;
Tiziano,Colibazzi [14]
;
Rebecca E,Cooper [15]
;
Cheryl M,Corcoran [16]
;
Vanessa L,Cropley [4]
;
Lieuwe,de Haan [17]
;
Camilo,de la Fuente-Sandoval [18]
;
Montserrat,Dolz [19]
;
Bjørn H,Ebdrup [20]
;
Adriana,Fortea [21]
;
Paolo,Fusar-Poli [22]
;
Louise Birkedal,Glenthøj [23]
;
Birte Yding,Glenthøj [20]
;
Shalaila S,Haas [24]
;
Holly K,Hamilton [25]
;
Kristen M,Haut [26]
;
Rebecca A,Hayes [6]
;
Ying,He [27]
;
Karsten,Heekeren [28]
;
Wenche Ten Velden,Hegelstad [29]
;
Christine I,Hooker [26]
;
Leslie E,Horton [10]
;
Daniela,Hubl [30]
;
Wu Jeong,Hwang [31]
;
Michael,Kaess [32]
;
Kiyoto,Kasai [33]
;
Naoyuki,Katagiri [34]
;
Minah,Kim [35]
;
Jochen,Kindler [36]
;
Mallory J,Klaunig [37]
;
Shinsuke,Koike [38]
;
Tina D,Kristensen [39]
;
Yoo Bin,Kwak [13]
;
Jun Soo,Kwon [40]
;
Stephen M,Lawrie [41]
;
Irina,Lebedeva [42]
;
Imke Lj,Lemmers-Jansen [43]
;
Pablo,León-Ortiz [18]
;
Ashleigh,Lin [44]
;
Rachel L,Loewy [45]
;
Xiaoqian,Ma [27]
;
Daniel H,Mathalon [46]
;
Patrick,McGorry [4]
;
Philip,McGuire [47]
;
Chantal,Michel [36]
;
Romina,Mizrahi [48]
;
Masafumi,Mizuno [49]
;
Paul,Møller [50]
;
Ricardo,Mora-Durán [51]
;
Daniel,Muñoz-Samons [52]
;
Barnaby,Nelson [4]
;
Takahiro,Nemoto [53]
;
Merete,Nordentoft [54]
;
Dorte,Nordholm [54]
;
Maria A,Omelchenko [55]
;
Lijun,Ouyang [56]
;
Christos,Pantelis [57]
;
Jose C,Pariente [58]
;
Jayachandra M,Raghava [59]
;
Paul E,Rasser [60]
;
Franz,Resch [61]
;
Francisco,Reyes-Madrigal [18]
;
Luis F,Rivera-Chávez [18]
;
Jan I,Røssberg [62]
;
Wulf,Rössler [63]
;
Dean F,Salisbury [10]
;
Daiki,Sasabayashi [64]
;
Ulrich,Schall [65]
;
Jason,Schiffman [66]
;
Andre,Schmidt [67]
;
Lukasz,Smigielski [68]
;
Mikkel E,Sørensen [39]
;
Gisela,Sugranyes [7]
;
Michio,Suzuki [64]
;
Tsutomu,Takahashi [64]
;
Christian K,Tamnes [69]
;
Jinsong,Tang [70]
;
Anastasia,Theodoridou [71]
;
Sophia I,Thomopoulos [72]
;
Alexander S,Tomyshev [42]
;
Jordina,Tor [52]
;
Peter J,Uhlhaas [73]
;
Tor G,Værnes [74]
;
Therese Amj,van Amelsvoort [75]
;
Dennis,Velakoulis [76]
;
Esther,Via [52]
;
Sophia,Vinogradov [77]
;
James A,Waltz [78]
;
Christina,Wenneberg [54]
;
Lars T,Westlye [79]
;
Stephen J,Wood [80]
;
Hidenori,Yamasue [81]
;
Liu,Yuan [56]
;
Alison R,Yung [82]
;
Michael Wl,Chee [1]
;
Paul M,Thompson [72]
;
Dennis,Hernaus [75]
;
Maria,Jalbrzikowski [15]
;
Jimmy,Lee [83]
;
Juan H,Zhou [84]
;
ENIGMA Clinical High Risk for Psychosis Working Group
作者单位：
Centre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.;Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
[1]
Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway.;Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Stockholm, Sweden.;KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.;Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
[2]
Dept of Neuroimaging, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.;WILL chair PSY team, Centre LilNCog, INSERM U-1172, Lille, Haute De France, France.
[3]
Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.;Orygen, Melbourne, VIC, Australia.
[4]
KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.;Centre for Precision Psychiatry, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
[5]
Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.
[6]
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.;Department of Child and Adolescent Psychiatry and Psychology, 2021SGR01319, Institute of Neuroscience, Hospital Clínic Barcelona, Barcelona, Spain.;Department of Medicine, Institute of Neuroscience, University of Barcelona, Barcelona, Spain.;Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
[7]
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.;NIHR Maudsley Biomedical Research Centre, South London and Maudsley NHS Foundation Trust and King's College London, London, UK.;Health Services and Population Research, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
[8]
Department of Psychiatry, University of Basel, Basel, Switzerland.;Department of Psychiatry and Psychotherapy, University of Lübeck, Lübeck, Germany.
[9]
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
[10]
Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
[11]
Department of Psychiatry, Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
[12]
Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.
[13]
Department of Psychiatry, Columbia University, New York City, NY, USA.;New York State Psychiatric Institute, New York City, NY, USA.
[14]
Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, Boston, MA, USA.;Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA.
[15]
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.;Mental Illness Research, Education, and Clinical Center, James J Peters VA Medical Center, New York City, NY, USA.
[16]
Department of Psychiatry, Amsterdam University Medical Centre, Amsterdam, The Netherlands.;Arkin, Amsterdam, The Netherlands.
[17]
Laboratory of Experimental Psychiatry, Instituto Nacional de Neurología y Neurocirugía, Mexico City, Mexico.
[18]
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.;Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.;Department of Child and Adolescent Mental Health, Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spain.
[19]
Center for Neuropsychiatric Schizophrenia Research, CNSR, and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Glostrup, Denmark.;Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
[20]
Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Barcelona, Spain.;Fundació de Recerca Clínic Barcelona-Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain.;Department of Psychiatry and Psychology, Institute of Neuroscience, Hospital Clinic Barcelona, Barcelona, Spain.
[21]
Early Psychosis: Interventions and Clinical-detection (EPIC) Lab, Department of Psychosis Studies, King's College London, London, UK.;Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy.;Outreach and Support in South-London (OASIS) service, South London and Maudlsey (SLaM) NHS Foundation Trust, London, UK.;Department of Psychiatry and Psychotherapy, University Hospital, Ludwig-Maximilian-University (LMU), Munich, Germany.
[22]
VIRTU Research Group, Mental Health Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark.
[23]
Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York City, NY, USA.
[24]
Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.;Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.;Mental Health Service, Minneapolis Veterans Affairs Health Care System, Minneapolis, MN, USA.
[25]
Department of Psychiatry and Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA.
[26]
Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
[27]
Department of Psychiatry and Psychotherapy I, LVR-Hospital Cologne, Cologne, Germany.;Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
[28]
Faculty of Social Sciences, University of Stavanger, Stavanger, Norway.;TIPS Centre for Clinical Research in Psychosis, Stavanger University Hospital, Stavanger, Norway.
[29]
Translational Research Center, University Hospital of Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
[30]
College of Medicine, Catholic Kwandong University, Gangneung, Republic of Korea.
[31]
Department of Child and Adolescent Psychiatry, Center of Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany.;University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
[32]
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.;The University of Tokyo Institute for Diversity and Adaptation of Human Mind, The University of Tokyo, Tokyo, Japan.;The International Research Center for Neurointelligence at The University of Tokyo Institutes for Advanced Study, The University of Tokyo, Tokyo, Japan.
[33]
Sakura Medical Center, Toho University, Chiba, Japan.
[34]
Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.;Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
[35]
University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland.
[36]
Department of Psychology, University of Maryland, Baltimore County, MD, USA.
[37]
The University of Tokyo Institute for Diversity and Adaptation of Human Mind, The University of Tokyo, Tokyo, Japan.;Center for Evolutionary Cognitive Sciences, Graduate School of Art and Sciences, The University of Tokyo, Tokyo, Japan.
[38]
Center for Neuropsychiatric Schizophrenia Research, CNSR, and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Glostrup, Denmark.
[39]
Department of Brain and Cognitive Sciences, Seoul National University College of Natural Sciences, Seoul, Republic of Korea.;Department of Neuropsychiatry, Seoul National University Hospital, Seoul, Republic of Korea.;Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea.
[40]
Division of Psychiatry, University of Edinburgh, Edinburgh, UK.
[41]
Laboratory of Neuroimaging and Multimodal Analysis, Mental Health Research Center, Moscow, Russia.
[42]
Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.;Faculty of Behavioural and Movement Sciences, Department of Clinical, Neuro and Developmental Psychology, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
[43]
School of Population and Global Health, The University of Western Australia, Crawley, WA, Australia.
[44]
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.
[45]
Department of Psychiatry and Behavioral Sciences, University of California San Francisco, San Francisco, CA, USA.;San Francisco Veterans Affairs Health Care System, San Francisco, CA, USA.
[46]
Department of Psychiatry, University of Oxford, Oxford, UK.
[47]
Douglas Research Center, Montreal, QC, Canada.;Department of Psychiatry, McGill University, Montreal, QC, Canada.
[48]
Tokyo Metropolitan Matsuzawa Hospital, Tokyo, Japan.
[49]
Department for Mental Health Research and Development, Division of Mental Health and Addiction, Vestre Viken Hospital Trust, Drammen, Norway.
[50]
Emergency Department, Hospital Fray Bernardino Álvarez, Mexico City, Mexico.
[51]
Child and Adolescent Mental Health Research Group, Institut de Recerca Sant Joan de Déu, Barcelona, Spain.;Department of Child and Adolescent Mental Health, Child and Adolescent Psychiatry and Psychology Department, Hospital Sant Joan de Déu, Barcelona, Spain.
[52]
Department of Neuropsychiatry, Toho University School of Medicine, Tokyo, Japan.
[53]
Copenhagen Research Center for Mental Health, Mental Health Center Copenhagen, University of Copenhagen, Copenhagen, Denmark.
[54]
Department of Youth Psychiatry, Mental Health Research Center, Moscow, Russia.
[55]
Department of Psychiatry, National Clinical Research Center for Mental Disorders, National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.;National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.;Hunan Key Laboratory of Psychiatry and Mental Health, the Second Xiangya Hospital, Central South University, Changsha, China.
[56]
Neuropsychiatry Theme, Department of Psychiatry, The University of Melbourne, Parkville, VIC, Australia.;Florey Institute of Neuroscience and Mental Health, Center for Mental Health, Parkville, VIC, Australia.;Monash Institute of Pharmaceutical Sciences (MIPS), Monash University, Royal Parade, Parkville, VIC, Australia.
[57]
Magnetic Resonance Imaging Core Facility, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
[58]
Center for Neuropsychiatric Schizophrenia Research, CNSR, and Center for Clinical Intervention and Neuropsychiatric Schizophrenia Research, CINS, Mental Health Center Glostrup, Glostrup, Copenhagen University Hospital - Mental Health Services CPH, Glostrup, Denmark.;Department of Clinical Physiology, Nuclear Medicine and PET, Functional Imaging Unit, University of Copenhagen, Glostrup, Denmark.
[59]
Priority Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.;Priority Research Centre for Stroke and Brain Injury, The University of Newcastle, Newcastle, NSW, Australia.
[60]
Clinic for Child and Adolescent Psychiatry, University Hospital of Heidelberg, Heidelberg, Germany.
[61]
Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
[62]
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.;Department of Psychiatry and Psychotherapy, Charité Universitätsmedizin Berlin, Berlin, Germany.
[63]
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, Toyama, Japan.;Research Center for Idling Brain Science, University of Toyama, Toyama, Japan.
[64]
Priority Centre for Brain and Mental Health Research, The University of Newcastle, Newcastle, NSW, Australia.;Priority Research Centre Grow Up Well, The University of Newcastle, Newcastle, NSW, Australia.
[65]
Department of Psychological Science, University of California Irvine, Irvine, CA, USA.
[66]
Department of Psychiatry, University of Basel, Basel, Switzerland.
[67]
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.;Department of Child and Adolescent Psychiatry, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
[68]
Division of Mental Health and Substance Abuse, Diakonhjemmet Hospital, Oslo, Norway.;PROMENTA Research Center, Department of Psychology, University of Oslo, Oslo, Norway.
[69]
Department of Psychiatry, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.;Key Laboratory of Medical Neurobiology of Zhejiang Province, School of Medicine, Zhejiang University, Hangzhou, China.
[70]
Department of Psychiatry, Psychotherapy and Psychosomatics, Psychiatric University Hospital Zurich, University of Zurich, Zurich, Switzerland.
[71]
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
[72]
Department of Child and Adolescent Psychiatry, Charité Universitätsmedizin, Berlin, Germany.;Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.
[73]
Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.;Early Intervention in Psychosis Advisory Unit for South-East Norway, TIPS Sør-Øst, Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway.
[74]
Department of Psychiatry and Neuropsychology, Mental Health and Neuroscience Research Institute, Faculty of Health Medicine and Life Sciences, Maastricht University, Maastricht, the Netherlands.
[75]
Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne & Melbourne Health, Carlton South, VIC, Australia.;Neuropsychiatry, The Royal Melbourne Hospital, Melbourne, VIC, Australia.
[76]
Department of Psychiatry & Behavioral Sciences, University of Minnesota, Minneapolis, MN, USA.
[77]
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA.
[78]
KG Jebsen Center for Neurodevelopmental Disorders, University of Oslo, Oslo, Norway.;Norwegian Centre for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.;Department of Psychology, University of Oslo, Oslo, Norway.
[79]
Centre for Youth Mental Health, University of Melbourne, Melbourne, VIC, Australia.;Orygen, Melbourne, VIC, Australia.;School of Psychology, University of Birmingham, Birmingham, UK.
[80]
Department of Psychiatry, Hamamatsu University School of Medicine, Hamamatsu City, Japan.
[81]
Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia.;School of Health Sciences, University of Manchester, Manchester, UK.
[82]
Department of Psychosis, Institute of Mental Health, Singapore, Singapore.;Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.
[83]
Centre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. helen.zhou@nus.edu.sg.;Centre for Translational Magnetic Resonance Research, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. helen.zhou@nus.edu.sg.;Department of Electrical and Computer Engineering, Integrative Sciences and Engineering Programme (ISEP), NUS Graduate School, National University of, Singapore, Singapore. helen.zhou@nus.edu.sg.
[84]
DOI
10.1038/s41380-025-03304-6
PMID
41125743
发布时间
2025-10-22
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Molecular psychiatry
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