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Exploration of imidazothiazole and imidazopyrimidine carboxamides for enhanced antitubercular activity.

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第一作者： Oluseye K,Onajole

第一单位： Department of Biological, Physical and Health Sciences, College of Health, Science and Pharmacy, Roosevelt University, 425 S. Wabash Avenue, Chicago, IL 60605, USA; Department of Pharmaceutical Sciences, University of Illinois Chicago College of Pharmacy, Chicago, IL 60612, USA. Electronic address: oonajole@roosevelt.edu.

作者： Oluseye K,Onajole ^[1] ; Shichun,Lun ^[2] ; Dakoju Ravi,Kishore ^[3] ; Anđela,Savić ^[4] ; Alexis,Morales ^[4] ; Alfredo,Guzman ^[4] ; Ethan,Schmidt ^[4] ; Adela,Lazzara ^[4] ; Gianna,Fajardo ^[4] ; Daniel P,Jamieson ^[4] ; A Jean-Luc,Ayitou ^[3] ; William R,Bishai ^[5]

作者单位： Department of Biological, Physical and Health Sciences, College of Health, Science and Pharmacy, Roosevelt University, 425 S. Wabash Avenue, Chicago, IL 60605, USA; Department of Pharmaceutical Sciences, University of Illinois Chicago College of Pharmacy, Chicago, IL 60612, USA. Electronic address: oonajole@roosevelt.edu. ^[1] Center for Tuberculosis Research, Dept. of Medicine, Div. of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, MD 21231-1044, USA. ^[2] Department of Chemistry, University of Illinois at Chicago, Chicago, IL 60607, USA. ^[3] Department of Biological, Physical and Health Sciences, College of Health, Science and Pharmacy, Roosevelt University, 425 S. Wabash Avenue, Chicago, IL 60605, USA. ^[4] Center for Tuberculosis Research, Dept. of Medicine, Div. of Infectious Disease, Johns Hopkins School of Medicine, Baltimore, MD 21231-1044, USA. Electronic address: wbishai1@jhmi.edu. ^[5]

关键词 Drug-resistant Mtb Imidazo[2,1-b]pyrimidine-5-carboxamides Imidazo[2,1-b]thiazole-5-carboxamides Imidazopyrimidine Imidothiazole Mycobacterium tuberculosis Structure–activity relationships