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3D correlative light and electron microscopy reveals the uptake and processing of inorganic-organic hybrid nanoparticles into cancer cells.

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第一作者： Louisa,Herbsleb

第一单位： Aalen University, Center for Optical Technologies, Anton-Huber-Straße 21, 73430, Aalen, Germany.

作者： Louisa,Herbsleb ^[1] ; David,Wild ^[1] ; Henriette,Gröger ^[2] ; Tim,Schubert ^[3] ; Anna Maria,Steyer ^[4] ; Julian,Hennies ^[4] ; Frauke,Alves ^[5] ; Claus,Feldmann ^[2] ; Andreas,Walter ^[6]

作者单位： Aalen University, Center for Optical Technologies, Anton-Huber-Straße 21, 73430, Aalen, Germany. ^[1] Institute of Inorganic Chemistry, Karlsruhe Institute of Technology (KIT), Engesserstr. 15, 76131, Karlsruhe, Germany. ^[2] Aalen University, Materials Research Institute Aalen, Beethovenstr. 1, 73430, Aalen, Germany. ^[3] EMBL Imaging Centre, European Molecular Biology Laboratory, 69117, Heidelberg, Germany. ^[4] Translational Molecular Imaging, Max-Planck-Institute for Multidisciplinary Sciences, 37075, Göttingen, Germany; Department for Haematology and Medical Oncology, Department of Clinical and Interventional Radiology, University Medical Center Göttingen, 37075, Göttingen, Germany. ^[5] Aalen University, Center for Optical Technologies, Anton-Huber-Straße 21, 73430, Aalen, Germany. Electronic address: andreas.walter@hs-aalen.de. ^[6]

关键词 Correlative light and electron microscopy (CLEM)Focused ion beam scanning electron microscopy (FIBSEM)Inorganic-organic nanoparticles (IOH-NP)Intracellular uptake and trafficking Quantitative confocal fluorescence microscopy