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scRNA-seq reveals persistent aberrant differentiation of nasal epithelium driven by TNFα and TGFβ in post-COVID syndrome.

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第一作者: K D,Reddy
第一单位: German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.;Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.;Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany.
作者单位: German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.;Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany.;Division of Epigenetics of Chronic Lung Diseases, Priority Area Chronic Lung Diseases, Research Center Borstel - Leibniz Lung Center, Borstel, Germany. [1] Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany. [2] Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany. [3] German Center for Lung Research (DZL), Airway Research Center North (ARCN), Borstel, Germany.;Department of Paediatric Pneumonology & Allergology, University Clinical Schleswig-Holstein (UKSH), Lübeck, Germany. [4] Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany. [5] Department of Otorhinolaryngology, Head and Neck Surgery, Christian-Albrechts-University Kiel and UKSH, Campus Kiel, Germany.;Department of Pneumology, Lungen Clinic Grosshansdorf, Grosshansdorf, Germany.;Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. [6] Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany.;Leibniz Lung Clinic, Department of Internal Medicine I, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany. [7] Leibniz Lung Clinic, Department of Internal Medicine I, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany. [8] Institute of Epidemiology, Kiel University, Kiel, Germany. [9] Centre of Allergy and Environment (ZAUM), Technische Universität and Helmholtz Centre Munich, Munich, Germany.;Comprehensive Pneumology Centre Munich (CPC-M), Member of The German Centre for Lung Research (DZL), LMU Munich, Germany. [10] Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany.;Biomedical Research in End stage and Obstructive Lung Disease Hannover (BREATH), Member of the German Centre of Lung Research (DZL), Hannover, Germany.;Cluster of Excellence RESIST (EXC 2155), German Research Foundation (DFG), Hannover Medical School, Hannover, Germany. [11] Comprehensive Pneumology Centre Munich (CPC-M), Member of The German Centre for Lung Research (DZL), LMU Munich, Germany.;Institute for Asthma and Allergy Prevention, Helmholtz Centre Munich, German Research Centre for Environmental Health, Neuherberg, Germany.;Department of Pulmonary and Allergy, Dr von Hauner University Children's Hospital, Ludwig Maximilian's University, LMU, Munich, Germany. [12] Department of Pneumology, Lungen Clinic Grosshansdorf, Grosshansdorf, Germany.;Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. [13] Comprehensive Pneumology Centre Munich (CPC-M), Member of The German Centre for Lung Research (DZL), LMU Munich, Germany.;Department of Pulmonary and Allergy, Dr von Hauner University Children's Hospital, Ludwig Maximilian's University, LMU, Munich, Germany.;German Center for Child and Adolescent Health (DZKJ), Dr von Hauner Children's Hospital, LMU, Munich, Germany. [14] Department of Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland. [15] Division of Medical Systems Biology, Institute of Experimental Dermatology, University of Luebeck, Luebeck, Germany. anke.faehnrich@uksh.de.;USKH Diagnostics Center, Universtiy Hospital Schleswig-Holstein, Lübeck, Germany. anke.faehnrich@uksh.de. [16]
DOI 10.1038/s41467-025-64778-0
PMID 41152229
发布时间 2025-11-01
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