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GZMK<sup>+</sup>CD8<sup>+</sup> T cells target a specific acinar cell type in Sjögren's disease.

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第一作者: Thomas J F,Pranzatelli
第一单位: Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Department of Biology, University of Maryland, College Park, Maryland, USA.
作者单位: Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Department of Biology, University of Maryland, College Park, Maryland, USA. [1] Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. [2] Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [3] Lab of Oral & Craniofacial Innovation, Department of Innovation & Technology Research, ADA Science & Research Institute, Gaithersburg, Maryland, USA. [4] Department of Biostatistics, Virginia Commonwealth University, Richmond, Virginia, USA. [5] T-lymphocyte Biology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA. [6] Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK. [7] Department of Dermatology, Michigan Medicine, University of Michigan, Ann Arbor, Michigan, USA. [8] Sjögren's Clinical Investigations Team, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. [9] Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Sjögren's Clinical Investigations Team, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. [10] Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [11] Consult Services Section, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA. [12] Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Lupus Clinical Trials Unit, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA. [13] Genes & Human Disease Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA. [14] Arthritis & Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA. [15] Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. [16] Genomics and Computational Biology Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, Maryland, USA. [17] Department of Biology, University of Maryland, College Park, Maryland, USA. [18] Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Sjögren's Clinical Investigations Team, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. [19] Massey Cancer Center, Virginia Commonwealth University, Richmond, Virginia, USA. [20] Matrix and Morphogenesis Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. [21] Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA. [22] Laboratory of Genitourinary Cancer Pathogenesis (LCGP) Microscopy Core Facility, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA. [23] Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Ensocell Therapeutics, BioData Innovation Centre, Wellcome Genome Campus, Cambridge, UK; Theory of Condensed Matter, Cavendish Laboratory/Department of Physics, University of Cambridge, Cambridge, UK; Department of Medicine, University of Cambridge, Cambridge, UK; CIFAR Macmillan Multi-scale Human Program, CIFAR, Toronto, Ontario, Canada. [24] Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Lab of Oral & Craniofacial Innovation, Department of Innovation & Technology Research, ADA Science & Research Institute, Gaithersburg, Maryland, USA; Department of Oral and Craniofacial Molecular Biology, Philips Institute for Oral Health Research, Virginia Commonwealth University, Richmond, Virginia, USA; VCU Massey Comprehensive Cancer Center, Bioinformatics Shared Resource Core, Virginia Commonwealth University, Richmond, Virginia, USA. [25] Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA; Sjögren's Clinical Investigations Team, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, USA. Electronic address: blake.warner@nih.gov. [26]
DOI 10.1016/j.ard.2025.08.014
PMID 41162286
发布时间 2026-05-09
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