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Discovery of novel 20S proteasome activators for hypoxic cardiomyocyte protection via endoplasmic reticulum stress alleviation.

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第一作者： Dan,Wu

第一单位： School of Medicine, Hangzhou City University, Hangzhou 310015, China.

作者： Dan,Wu ^[1] ; Yu,Cao ^[2] ; Yubing,Han ^[3] ; Linhao,Xu ^[4] ; Han,Han ^[1] ; Yaoli,Shi ^[1] ; Jiayi,Ma ^[1] ; Qingyi,Wang ^[1] ; Lixin,Gao ^[5] ; Mingzhi,Wang ^[6] ; Jianjun,Xi ^[2] ; Jingjing,Sun ^[2] ; Huajian,Zhu ^[1] ; Jiaan,Shao ^[1] ; Bin,Ju ^[7] ; Yizhou,Xu ^[8] ; Yubo,Zhou ^[9] ; Jiankang,Zhang ^[10]

作者单位： School of Medicine, Hangzhou City University, Hangzhou 310015, China. ^[1] Department of Pharmaceutical Preparation, Hangzhou Xixi Hospital, Hangzhou 310023, Zhejiang Province, China. ^[2] Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[3] Department of Cardiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China. ^[4] State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. ^[5] Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China. ^[6] Hangzhou SanOmics Information Technology Co., Ltd., Hangzhou 310015, PR China. ^[7] Department of Cardiology, Affiliated Hangzhou First People's Hospital, School of Medicine, Westlake University, Hangzhou 310006, Zhejiang Province, China. Electronic address: xuyizhou@hospital.westlake.edu.cn. ^[8] Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Zhongshan 528400, China; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Electronic address: ybzhou@simm.ac.cn. ^[9] School of Medicine, Hangzhou City University, Hangzhou 310015, China. Electronic address: zhang_jk@hzcu.edu.cn. ^[10]

关键词 20S proteasome activator ER stress Hypoxic cardiomyocyte protection Proteostasis Screening and optimization