首页> Journal of pharmaceutical sciences> Demonstration of in vitro-in vivo relationship (IVIVR) and virtual bioequivalence (VBE) between progesterone intravaginal rings using physiologically based pharmacokinetic (PBPK) modelling.

Demonstration of in vitro-in vivo relationship (IVIVR) and virtual bioequivalence (VBE) between progesterone intravaginal rings using physiologically based pharmacokinetic (PBPK) modelling.

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第一作者： Kanika,Thakur

第一单位： Certara UK Limited, Predictive Technologies Division, Level 2-Acero, 1 Concourse Way, Sheffield S1 2BJ, UK. Electronic address: kanika.thakur@certara.com.

作者： Kanika,Thakur ^[1] ; Ola,Sternebring ^[2] ; Yu-E,Zhang ^[3] ; Kevin,Wyckoff ^[3] ; Iain,Macdonald ^[4] ; Philippe,Pinton ^[2] ; Daniel,Paterson ^[5] ; Krishna Chaitanya,Telaprolu ^[5] ; Sebastian,Polak ^[6]

作者单位： Certara UK Limited, Predictive Technologies Division, Level 2-Acero, 1 Concourse Way, Sheffield S1 2BJ, UK. Electronic address: kanika.thakur@certara.com. ^[1] Ferring Pharmaceuticals A/S, Global Research & Medical, Kastrup, Denmark. ^[2] Ferring Pharmaceuticals Inc., Parsippany, New Jersey, USA. ^[3] Ferring Controlled Therapeutics Limited, Glasgow, UK. ^[4] Certara UK Limited, Predictive Technologies Division, Level 2-Acero, 1 Concourse Way, Sheffield S1 2BJ, UK. ^[5] Certara UK Limited, Predictive Technologies Division, Level 2-Acero, 1 Concourse Way, Sheffield S1 2BJ, UK; Chair of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Jagiellonian University Medical College, Medinan 9, 30-688 Krakow, Poland. ^[6]

关键词 Absorption In vitro-In vivo relation Mechanistic modelling Permeability coefficient Pharmacokinetics Physiologically based pharmacokinetic modelling (PBPK)