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PRDM15 promotes colorectal carcinogenesis by transcriptionally repressing USP10 to destabilize p53.

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第一作者： Chongyang,Wu

第一单位： Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China.

作者： Chongyang,Wu ^[1] ; Wenzhe,Si ^[2] ; Hanxiao,Li ^[1] ; Jie,Sheng ^[1] ; Fei,Pei ^[3] ; Xujun,Liu ^[4] ; Xinping,Su ^[1] ; Ying,Wang ^[1] ; Cihang,Liu ^[1] ; Yihua,Zhang ^[1] ; Bin,Jiang ^[1] ; Wengong,Wang ^[1] ; Xia,Yi ^[5]

作者单位： Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. ^[1] Department of Laboratory Medicine, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University Third Hospital, Beijing, 100191, China. ^[2] Department of Pathology, Peking University Health Science Center, Beijing, 100191, China. ^[3] Department of Laboratory Medicine, Peking University First Hospital, Beijing, 100034, China. ^[4] Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences, Peking University Health Science Center, 38 Xueyuan Road, Beijing, 100191, China. Electronic address: yixia@bjmu.edu.cn. ^[5]

关键词 Colorectal cancer (CRC)PRDM15 Tumorigenesis USP10 p53