首页> Blood cancer discovery> Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency.

Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency.

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第一作者： Juan M,Barajas

第一单位： Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.

作者： Juan M,Barajas ^[1] ; Aaron H,Phillips ^[2] ; Jina,Wang ^[2] ; Melvin E,Thomas ^[1] ; Lisett,Contreras ^[1] ; Masayuki,Umeda ^[1] ; Ryan,Hiltenbrand ^[1] ; Elizabeth,Caldwell ^[1] ; Michael P,Walsh ^[1] ; Guangchun,Song ^[1] ; Lauren,Ezzell ^[3] ; Kelly,Churion ^[2] ; Tamara,Westover ^[1] ; Emily,Xiong ^[1] ; Chandra,Rolle ^[1] ; Jamila,Moore ^[4] ; Josi,Lott ^[5] ; Sandi,Radko-Juettner ^[1] ; Amit,Kumar ^[5] ; Wenjie,Qi ^[6] ; Beisi,Xu ^[6] ; Evangelia K,Papachristou ^[7] ; Clive S,D'Santos ^[7] ; Jing,Ma ^[1] ; Burgess B,Freeman ^[8] ; Laura J,Janke ^[1] ; Richard W,Kriwacki ^[9] ; Jeffery M,Klco ^[10]

作者单位： Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee. ^[1] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee. ^[2] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.;Graduate School of Biomedical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee. ^[3] Preclinical Therapeutics Program, St. Jude Children's Research Hospital, Memphis, Tennessee. ^[4] Center of Excellence for Leukemia Studies (CELS), St. Jude Children's Research Hospital, Memphis, Tennessee. ^[5] Center for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, Tennessee. ^[6] Cancer Research UK Cambridge Institute, Li Ka Shing Centre, University of Cambridge, Cambridge, United Kingdom. ^[7] Preclinical Pharmacokinetics Shared Resources, St. Jude Children's Research Hospital, Memphis, Tennessee. ^[8] Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee.;Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Sciences Center, Memphis, Tennessee. ^[9] Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee.;Center of Excellence for Leukemia Studies (CELS), St. Jude Children's Research Hospital, Memphis, Tennessee. ^[10]

医学主题词人类(Humans);核胞浆转运蛋白类(Karyopherins);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);出核转运信号肽(Nuclear Export Signals);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);小鼠(Mice);动物(Animals);串联重复序列(Tandem Repeat Sequences);基因复制(Gene Duplication)

DOI 10.1158/2643-3230.BCD-25-0112

PMID 41182175

发布时间 2026-01-14

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Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency.

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Tandem Duplications in UBTF Create XPO1-Dependent Nuclear Export Signals that Reveal a Leukemic Therapeutic Dependency.

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