首页> Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology> Thrombomodulin-Induced Prevention of Peripheral Neuropathy in Oxaliplatin-Treated Mice Involves Complement C5a Inactivation and PAR1 Activation in Addition To HMGB1 Degradation.

Thrombomodulin-Induced Prevention of Peripheral Neuropathy in Oxaliplatin-Treated Mice Involves Complement C5a Inactivation and PAR1 Activation in Addition To HMGB1 Degradation.

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第一作者： Kengo,Maruo

第一单位： Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi, 577-8502, Osaka, Japan.

作者： Kengo,Maruo ^[1] ; Maho,Tsubota ^[1] ; Kazuki,Tajima ^[1] ; Hiroaki,Matsunaga ^[1] ; Fumiko,Sekiguchi ^[1] ; Tatsuro,Minami ^[2] ; Akitoshi,Ito ^[2] ; Yasuko,Tomono ^[3] ; Masahiro,Nishibori ^[3] ; Atsufumi,Kawabata ^[4]

作者单位： Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi, 577-8502, Osaka, Japan. ^[1] Pharmaceuticals Research Center, Asahi Kasei Pharma Co. Ltd, 632-1 Mifuku, Izunokuni, 410-2321, Japan. ^[2] Department of Translational Research and Drug Development, Dentistry and Pharmaceutical Sciences, Okayama University Graduate School of Medicine, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan. ^[3] Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University, 3-4-1 Kowakae, Higashi, 577-8502, Osaka, Japan. kawabata@phar.kindai.ac.jp. ^[4]

关键词 Activated protein c (APC)Activated thrombin-activatable fibrinolysis inhibitor (TAFIa)Complement C5a High mobility group box 1 (HMGB1)Oxaliplatin-induced peripheral neuropathy Thrombomodulin alfa