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A novel long-acting C5a-blocking cyclic peptide prevents sepsis-induced organ dysfunction via effective blockade of the inflammatory cascade.

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第一作者： Zimiao,Luo

第一单位： Department of Burn Surgery, Burn Institute of PLA, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. luo_zimiao@163.com.

作者： Zimiao,Luo ^[1] ; Pengfei,Luo ^[2] ; Haoyu,Gu ^[2] ; Xiaoyan,Hu ^[2] ; Shichu,Xiao ^[2] ; Weiyue,Lu ^[3] ; Zhaofan,Xia ^[4]

作者单位： Department of Burn Surgery, Burn Institute of PLA, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. luo_zimiao@163.com. ^[1] Department of Burn Surgery, Burn Institute of PLA, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. ^[2] Department of Pharmaceutics, School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery (Fudan University), Ministry of Education and PLA, Shanghai, 201203, China; National Key Laboratory of Advanced Drug Formulations for Overcoming Delivery Barriers, Shanghai, 201203, China. wylu@shmu.edu.cn. ^[3] Department of Burn Surgery, Burn Institute of PLA, The First Affiliated Hospital of Naval Medical University, Shanghai, 200433, China. xiazhaofan_smmu@163.com. ^[4]

医学主题词动物(Animals);脓毒症(Sepsis);肽类, 环(Peptides, Cyclic);小鼠(Mice);补体C5a(Complement C5a);炎症(Inflammation);人类(Humans);多器官功能衰竭(Multiple Organ Failure);男(雄)性(Male);疾病模型, 动物(Disease Models, Animal)

DOI 10.1038/s41392-025-02457-8

PMID 41188260

发布时间 2025-11-07

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Signal transduction and targeted therapy

2025年10卷1期

362页

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Signal transduction and targeted therapy

2025年10卷1期

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A novel long-acting C5a-blocking cyclic peptide prevents sepsis-induced organ dysfunction via effective blockade of the inflammatory cascade.

Signal transduction and targeted therapy

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A novel long-acting C5a-blocking cyclic peptide prevents sepsis-induced organ dysfunction via effective blockade of the inflammatory cascade.

Signal transduction and targeted therapy

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Signal transduction and targeted therapy

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