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Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression.

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第一作者： Emily G,Shuldiner

第一单位： Department of Biology, Stanford University, Stanford, CA, USA.

作者： Emily G,Shuldiner ^[1] ; Saswati,Karmakar ^[2] ; Min K,Tsai ^[3] ; Jess D,Hebert ^[2] ; Yuning J,Tang ^[2] ; Laura,Andrejka ^[2] ; Maggie R,Robertson ^[4] ; Minwei,Wang ^[2] ; Colin R,Detrick ^[2] ; Hongchen,Cai ^[2] ; Rui,Tang ^[2] ; Christian A,Kunder ^[5] ; David M,Feldser ^[4] ; Dmitri A,Petrov ^[6] ; Monte M,Winslow ^[7]

作者单位： Department of Biology, Stanford University, Stanford, CA, USA. ^[1] Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. ^[2] Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.;Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA. ^[3] Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Cell and Molecular Biology Graduate Group, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.;Abramson Family Cancer Research Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[4] Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. ^[5] Department of Biology, Stanford University, Stanford, CA, USA. dpetrov@stanford.edu.;Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA. dpetrov@stanford.edu.;The Chan Zuckerberg BioHub, San Francisco, CA, USA. dpetrov@stanford.edu. ^[6] Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA. mwinslow@stanford.edu.;Cancer Biology Program, Stanford University School of Medicine, Stanford, CA, USA. mwinslow@stanford.edu.;Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. mwinslow@stanford.edu. ^[7]

医学主题词动物(Animals);肺肿瘤(Lung Neoplasms);PTEN磷酸水解酶(PTEN Phosphohydrolase);衰老(Aging);小鼠(Mice);原癌基因蛋白质类p21(ras)(Proto-Oncogene Proteins p21(ras));人类(Humans);细胞转化, 肿瘤(Cell Transformation, Neoplastic);肿瘤微环境(Tumor Microenvironment);基因, 肿瘤抑制(Genes, Tumor Suppressor);疾病模型, 动物(Disease Models, Animal)

DOI 10.1038/s43587-025-00986-z

PMID 41188600

发布时间 2026-03-12

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Nature aging

2025年5卷11期

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Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression.

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Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression.

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