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Mouse-adapted SARS-CoV-2 Omicron BA.5 infection induces post-acute lung fibrosis in BALB/c mice.

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第一作者： John M,Powers

第一单位： Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

作者： John M,Powers ^[1] ; Sarah R,Leist ^[1] ; Naveenchandra,Suryadevara ^[2] ; Seth J,Zost ^[2] ; Elad,Binshtein ^[2] ; Anfal,Abdelgadir ^[3] ; Michael L,Mallory ^[1] ; Caitlin E,Edwards ^[1] ; Kendra L,Gully ^[1] ; Miranda L,Hubbard ^[1] ; Mark R,Zweigart ^[1] ; Alexis B,Bailey ^[1] ; Timothy P,Sheahan ^[4] ; James E,Crowe ^[5] ; Stephanie A,Montgomery ^[6] ; Jack R,Harkema ^[7] ; Ralph S,Baric ^[4]

作者单位： Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. ^[1] Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. ^[2] Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. ^[3] Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.;Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. ^[4] Vanderbilt Center for Antibody Therapeutics, Vanderbilt University Medical Center, Nashville, Tennessee, USA.;Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.;Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA. ^[5] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.;Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. ^[6] Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, Michigan, USA. ^[7]

关键词 SARS-CoV-2 Omicron BA.5 fibrotic lung disease monoclonal antibodies mouse models sarbecovirus