首页> Molecular cell> UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance.

UDP-GlcUA triggers PKR kinase activity to promote liquid-liquid phase separation of TOP2A and enhances radioimmunotherapy resistance.

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第一作者： Hua,Yu

第一单位： School of Life Sciences, Guangzhou University, Guangzhou, Guangdong 510006, China.

作者： Hua,Yu ^[1] ; Tiezhu,Shi ^[1] ; Huiying,Chu ^[2] ; Dongwei,Xu ^[3] ; Xiaoyong,Gong ^[4] ; Lingyun,Xiao ^[1] ; Ye,Liu ^[5] ; Qiang,Xia ^[3] ; Qi,Zhou ^[6] ; Yufeng,Ding ^[7] ; Guohui,Li ^[8] ; Xiongjun,Wang ^[9]

作者单位： School of Life Sciences, Guangzhou University, Guangzhou, Guangdong 510006, China. ^[1] Interdisciplinary Research Center for Biology and Chemistry, Liaoning Normal University, Dalian, Liaoning 116029, China; State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. ^[2] Department of Liver Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. ^[3] Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of General Surgery, Ruijin-hainan Hospital, Shanghai Jiao Tong University School of Medicine, Hainan 571437, China. ^[4] State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. ^[5] Department of Liver Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China; Department of General Surgery, Hui Ya Hospital of The First Affiliated Hospital, Sun Yat-sen University, Huizhou, Guangdong 516081, China. Electronic address: zhouqi@mail.sysu.edu.cn. ^[6] School of Life Sciences, Guangzhou University, Guangzhou, Guangdong 510006, China. Electronic address: yfding@sibs.ac.cn. ^[7] Interdisciplinary Research Center for Biology and Chemistry, Liaoning Normal University, Dalian, Liaoning 116029, China; State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China. Electronic address: ghli@dicp.ac.cn. ^[8] School of Life Sciences, Guangzhou University, Guangzhou, Guangdong 510006, China. Electronic address: wangxiongjun@gzhu.edu.cn. ^[9]

关键词 LLPS PKR TOP2A UGDH liver cancer metabolite