首页> Journal of chromatography. A> From reaction energetics to automated analysis tool auxiliary identification: A self-validating multidimensional liquid chromatography- mass spectrometry framework for characterizing polymerized impurities in carbapenem antibiotics.

From reaction energetics to automated analysis tool auxiliary identification: A self-validating multidimensional liquid chromatography- mass spectrometry framework for characterizing polymerized impurities in carbapenem antibiotics.

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第一作者： Fan,Wang

第一单位： Zhejiang Institute for Food and Drug Control, Key Laboratory for Core Technology of Generic Drug Evaluation National Medical Product Administration & Key Laboratory of Drug Contacting Materials Quality Control of Zhejiang Province, Hangzhou, 310052, China; Faculty of Medicine and Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

作者： Fan,Wang ^[1] ; Rongkang,Mu ^[2] ; Xin,Chen ^[2] ; Xiaoying,Yin ^[2] ; Fangyu,Zhou ^[3] ; Yiren,Song ^[2] ; Kexin,Guo ^[2] ; Xuan,Mao ^[2] ; Haochen,Zhai ^[2] ; Tonglin,Fan ^[2] ; Zhangyi,Chen ^[2] ; Bingxing,Zhang ^[4] ; Bingqi,Zhu ^[5] ; Peilin,Yu ^[2] ; Zhihao,Xu ^[6] ; Jian,Wang ^[7] ; Liya,Hong ^[8]

作者单位： Zhejiang Institute for Food and Drug Control, Key Laboratory for Core Technology of Generic Drug Evaluation National Medical Product Administration & Key Laboratory of Drug Contacting Materials Quality Control of Zhejiang Province, Hangzhou, 310052, China; Faculty of Medicine and Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. ^[1] Faculty of Medicine and Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. ^[2] School of Computer Science, University of Liverpool, Liverpool L69 3BX, United Kingdom. ^[3] Department of Electrical Engineering and Computer Science, University of Michigan, Ann Arbor, 1301 Beal Avenue, Ann Arbor, MI 48109, USA. ^[4] Zhejiang Chinese Medical University, Hangzhou 310058, China. ^[5] Department of Respiratory and Critical Care Medicine, The Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, China. Electronic address: xuzhihao@zju.edu.cn. ^[6] Zhejiang Institute for Food and Drug Control, Key Laboratory for Core Technology of Generic Drug Evaluation National Medical Product Administration & Key Laboratory of Drug Contacting Materials Quality Control of Zhejiang Province, Hangzhou, 310052, China; Zhejiang University of Technology, Hangzhou, 310014, China. Electronic address: wangjianhw2000@163.com. ^[7] Zhejiang Institute for Food and Drug Control, Key Laboratory for Core Technology of Generic Drug Evaluation National Medical Product Administration & Key Laboratory of Drug Contacting Materials Quality Control of Zhejiang Province, Hangzhou, 310052, China. Electronic address: lyhong987@163.com. ^[8]

关键词 2D HPSEC×LC-Q-Exactive MS Carbapenems Dimerization mechanism HPSEC Polymerized impurities Theoretical calculations UHPLC-Q-TOF MS

医学主题词色谱法, 高压液相(Chromatography, High Pressure Liquid);卡巴配能类(Carbapenems);药物污染(Drug Contamination);抗菌药(Anti-Bacterial Agents);串联质谱法(Tandem Mass Spectrometry);聚合(Polymerization);结果可重复性(Reproducibility of Results)

DOI 10.1016/j.chroma.2025.466511

PMID 41205485

发布时间 2025-12-04

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