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Genome-wide association studies of TDP-43 proteinopathy and hippocampal sclerosis reveal shared genetic associations with APOE and TMEM106B.

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第一作者: Dana,Godrich
第一单位: Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA.
作者单位: Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA. [1] John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA. [2] Dr. John T. MacDonald Foundation Department of Human Genetics, Miller School of Medicine, University of Miami, Miami, Florida, USA.;John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA. [3] Department of Biostatistics, Epidemiology, and Informatics, Penn Neurodegeneration Genomics Center, Philadelphia, Pennsylvania, USA. [4] Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. [5] Vanderbilt Memory & Alzheimer's Center, Vanderbilt University Medical Center, Nashville, Tennessee, USA. [6] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, New York, USA. [7] Kaiser Permanente Washington Health Research Institute, Seattle, Washington, USA. [8] Department of Medicine, University of Washington, Seattle, Washington, USA. [9] Department of Pathology, University of Washington, Seattle, Washington, USA. [10] University of Pittsburgh, Pittsburgh, Pennsylvania, USA. [11] Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA. [12] Neurology Service, Hospital Clínic, Fundació Recerca Clínic Barcelona (FRCB). Institut d'Investigacions Biomediques August Pi I Sunyer (IDIBAPS), University of Barcelona, Sarrià-Sant Gervasi, Barcelona, Spain. [13] Department of Neurology and Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA. [14] Department of Pathology, Stanford University School of Medicine, Stanford, California, USA. [15]
DOI 10.1002/alz.70760
PMID 41208712
发布时间 2025-11-14
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Alzheimer's & dementia : the journal of the Alzheimer's Association

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