首页> Molecular pharmaceutics> Confounding Effect of Hepatic Carboxylesterase 1 (CES1) Variability on Clopidogrel Oxidation.

Confounding Effect of Hepatic Carboxylesterase 1 (CES1) Variability on Clopidogrel Oxidation.

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第一作者： Sandhya,Subash

第一单位： College of Pharmacy and Pharmaceutical Sciences, Washington State University (WSU), Spokane, Washington 99202, United States.

作者： Sandhya,Subash ^[1] ; Dilip K,Singh ^[1] ; S Cyrus,Khojasteh ^[2] ; Bernard P,Murray ^[3] ; Michael A,Zientek ^[4] ; Robert S,Jones ^[2] ; Priyanka,Kulkarni ^[5] ; Bill J,Smith ^[6] ; Bhagwat,Prasad ^[1]

作者单位： College of Pharmacy and Pharmaceutical Sciences, Washington State University (WSU), Spokane, Washington 99202, United States. ^[1] Drug Metabolism and Pharmacokinetics, Genentech, Inc., South San Francisco, California 94080, United States. ^[2] Drug Metabolism, Gilead Sciences, Inc., Foster City, California 94404, United States. ^[3] Drug Metabolism and Pharmacokinetics, Takeda Development Center Americas, Inc., San Diego, California 92121, United States. ^[4] Drug Metabolism and Pharmacokinetics, Takeda Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, United States. ^[5] Terminal Phase Consulting LLC, Colorado Springs, Colorado 94404, United States. ^[6]

关键词 CES1 CYP clopidogrel fraction metabolized

医学主题词人类(Humans);羧酸酯水解酶类(Carboxylic Ester Hydrolases);氧化还原(Oxidation-Reduction);微粒体, 肝(Microsomes, Liver);噻氯匹定(Ticlopidine);肝(Liver);蛋白质组学(Proteomics)

DOI 10.1021/acs.molpharmaceut.5c00462

PMID 41232930

发布时间 2025-12-05

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