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The SLC1A1/EAAT3 dicarboxylic amino acid transporter is an epigenetically dysregulated nutrient carrier that sustains oncogenic metabolic programs.

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第一作者： Treg,Grubb

第一单位： Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.

作者： Treg,Grubb ^[1] ; Pooneh,Koochaki ^[1] ; Sayed,Matar ^[2] ; Fatme,Ghandour ^[2] ; Marc,Machaalani ^[3] ; Eddy,Saad ^[3] ; Cerise,Tang ^[4] ; Eduard,Reznik ^[4] ; Jesminara,Khatun ^[1] ; Carleigh,Salem ^[1] ; Noah,Dubasik ^[1] ; David A,Orlando ^[5] ; Matthew G,Guenther ^[5] ; Gyanu,Parajuli ^[6] ; Raghvendra M,Srivastava ^[6] ; Steven R,Martinez ^[7] ; Jesse A,Coker ^[7] ; Ritesh R,Kotecha ^[8] ; A Ari,Hakimi ^[9] ; John M,Asara ^[10] ; Timothy A,Chan ^[6] ; Sakari,Vanharanta ^[11] ; Shaun R,Stauffer ^[7] ; William G,Kaelin ^[12] ; Sabina,Signoretti ^[2] ; Toni K,Choueiri ^[3] ; Abhishek A,Chakraborty ^[13]

作者单位： Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. ^[1] Department of Pathology, Brigham and Women's Hospital, Boston, MA, USA. ^[2] Department of Medical Oncology, Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. ^[3] Computational Oncology, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[4] Syros Pharmaceuticals Inc., Cambridge, MA, USA. ^[5] Center for Immunotherapy and Precision Oncology, Lerner Research Institute, Cleveland Clinic, Cleveland, USA. ^[6] Center for Therapeutics Discovery, Cleveland Clinic, Cleveland, OH, USA. ^[7] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[8] Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[9] Mass Spectrometry Core, Beth Israel Deaconess Medical Center, Department of Medicine, Harvard Medical School, Boston, MA, USA. ^[10] Translational Cancer Medicine Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland. ^[11] Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.;Howard Hughes Medical Institute, Chevy Chase, MD, USA. ^[12] Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. chakraa@ccf.org.;Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA. chakraa@ccf.org.;Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH, USA. chakraa@ccf.org. ^[13]