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Discovery of novel pyrimidine-based KRAS-G12C inhibitors with potent anti-NSCLC activity via virtual screening and structure optimization.

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第一作者： Jian-Tao,Shi

第一单位： School of Pharmacy, Collaborative Innovation Center for Northwestern Chinese Medicine, and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China.

作者： Jian-Tao,Shi ^[1] ; Su-Juan,Hou ^[1] ; Cheng-Long,Xu ^[2] ; Lei,Cheng ^[1] ; Feng-Ya,Ge ^[1] ; Xiu-Juan,Liu ^[1] ; Yi-Ru,Wang ^[1] ; Xi-Bo,Wang ^[1] ; Yao-Sheng,Zhang ^[1] ; Junmin,Zhang ^[3] ; Shi-Wu,Chen ^[4]

作者单位： School of Pharmacy, Collaborative Innovation Center for Northwestern Chinese Medicine, and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China. ^[1] School of Pharmaceutical Sciences, Guangdong Provincial Key Laboratory of New Drug Screening, Southern Medical University, Guangzhou, 510515, China. ^[2] School of Pharmacy, Collaborative Innovation Center for Northwestern Chinese Medicine, and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China. Electronic address: zhangjunmin@lzu.edu.cn. ^[3] School of Pharmacy, Collaborative Innovation Center for Northwestern Chinese Medicine, and State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, 730000, China. Electronic address: chenshw@lzu.edu.cn. ^[4]

关键词 Apoptosis KRAS-G12C NSCLC Pyrimidine Structure-activity relationship