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A Machine Learning-Empowered Quantitative Structure-Activity Relationship Model for Predicting the Plasma Half-life of Drugs in Dogs.

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第一作者： Xue,Wu

第一单位： Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, 2187 Mowry Road, Gainesville, Florida, 32611, USA.;Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida, 32611, USA.;Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, 32827, USA.

作者： Xue,Wu ^[1] ; Pei-Yu,Wu ^[1] ; Wei-Chun,Chou ^[2] ; Lisa A,Tell ^[3] ; Zhoumeng,Lin ^[4]

作者单位： Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, 2187 Mowry Road, Gainesville, Florida, 32611, USA.;Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida, 32611, USA.;Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, 32827, USA. ^[1] Department of Environmental Sciences, College of Natural and Agricultural Sciences, University of California, Riverside, California, 92521, USA. ^[2] Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California-Davis, Davis, California, 95616, USA. ^[3] Department of Environmental and Global Health, College of Public Health and Health Professions, University of Florida, 2187 Mowry Road, Gainesville, Florida, 32611, USA. linzhoumeng@ufl.edu.;Center for Environmental and Human Toxicology, University of Florida, Gainesville, Florida, 32611, USA. linzhoumeng@ufl.edu.;Center for Pharmacometrics and Systems Pharmacology, University of Florida, Orlando, Florida, 32827, USA. linzhoumeng@ufl.edu. ^[4]

关键词 New Approach Methodologies (NAMs)Quantitative Structure–Activity Relationship (QSAR) Modeling machine learning pharmacokinetics plasma half-life

医学主题词动物(Animals);狗(Dogs);半衰期(Half-Life);量化构效关系(Quantitative Structure-Activity Relationship);模型, 生物学(Models, Biological);药用制剂(Pharmaceutical Preparations)

DOI 10.1208/s12248-025-01170-2

PMID 41254440

发布时间 2026-05-08

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