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Engineering a spatiotemporal macrophage circuit via STING phase separation to override immune suppression in pancreatic cancer.

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第一作者： Xue,Yang

第一单位： Department of Radiology, Nurturing Center of Jiangsu Province for State Laboratory of Artificial Intelligence Imaging and Interventional Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China.

作者： Xue,Yang ^[1] ; Yinlu,Wang ^[2] ; Jiaxin,Zhou ^[2] ; Siyu,Li ^[1] ; Jin,Ye ^[2] ; Yu,Sun ^[2] ; Mengning,He ^[2] ; Kai,Fan ^[1] ; Zixin,Chen ^[1] ; Fangzheng,Tian ^[1] ; Ben,Zhao ^[1] ; Jianqiong,Zhang ^[3] ; Jinbing,Xie ^[3] ; Zebin,Xiao ^[1] ; Xiaoyuan,Chen ^[4] ; Shenghong,Ju ^[1]

作者单位： Department of Radiology, Nurturing Center of Jiangsu Province for State Laboratory of Artificial Intelligence Imaging and Interventional Radiology, Zhongda Hospital, Medical School, Southeast University, Nanjing 210009, China. ^[1] Department of Pharmaceutics, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, China. ^[2] Department of Microbiology and Immunology, Medical School, Southeast University, Nanjing 210009, China. ^[3] Department of Diagnostic Radiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119074, Singapore.;Department of Chemical and Biomolecular Engineering, College of Design and Engineering, National University of Singapore, Singapore 117575, Singapore.;Department of Biomedical Engineering, College of Design and Engineering, National University of Singapore, Singapore 117575, Singapore.;Department of Pharmacy and Pharmaceutical Sciences, Faculty of Science, National University of Singapore, Singapore 117544, Singapore.;Clinical Imaging Research Centre, Centre for Translational Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117599, Singapore.;Nanomedicine Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.;Theranostics Center of Excellence, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 138667, Singapore. ^[4]

关键词 PDAC biomimetic tumor associated macrophages tumor metastasis