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Genome-scale Metabolic Modeling Guided Escherichia coli Engineering for De Novo Biosynthesis of Chrysanthemic Acid.

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第一作者： Jiangpeng,Yu

第一单位： Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, China.;College of Plant & Technology, Huazhong Agricultural University, Wuhan, 430070, China.

作者： Jiangpeng,Yu ^[1] ; Kelin,Cheng ^[2] ; Shenyang,Qu ^[2] ; Jie,Wang ^[2] ; Xun,Wang ^[3] ; Cheng,Zhao ^[2] ; Wei,Li ^[2]

作者单位： Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, China.;College of Plant & Technology, Huazhong Agricultural University, Wuhan, 430070, China. ^[1] Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Key Laboratory of Synthetic Biology, Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences, Shenzhen, 518124, China. ^[2] National Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China. ^[3]

关键词 E. coli Genome‐scale metabolic model cell factory chrysanthemic acid debranching strategy

医学主题词大肠杆菌(Escherichia coli);代谢网络和途径(Metabolic Networks and Pathways);生物合成途径(Biosynthetic Pathways);模型, 生物学(Models, Biological)

DOI 10.1002/advs.202512736

PMID 41268691

发布时间 2026-01-11

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