首页> Bioorganic & medicinal chemistry> Novel oxadiazole analogs as anticancer agents: Design, synthesis, in vitro and in vivo biological evaluation, and computer studies of sphingosine kinase inhibitors.

Novel oxadiazole analogs as anticancer agents: Design, synthesis, in vitro and in vivo biological evaluation, and computer studies of sphingosine kinase inhibitors.

导出 LinkOut

翻译打印收藏纠错

第一作者： Fuxun,Huang

第一单位： School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan 250117, PR China.

作者： Fuxun,Huang ^[1] ; Xinmei,Yang ^[2] ; Haiyang,Wang ^[1] ; Xiujuan,Shi ^[1] ; Xiaodong,Zhao ^[1] ; Junru,Liu ^[1] ; Yueyang,Sun ^[1] ; Xingbo,Song ^[1] ; Tong,Li ^[1] ; Zhaoyang,Li ^[2] ; Xi,Qiu ^[2] ; Jingtong,Feng ^[1] ; Yuanyuan,Liu ^[1] ; Yuqi,Gao ^[1] ; Yanling,Mu ^[1] ; Zhengguo,Cui ^[3] ; Peng,Zhan ^[4] ; Bo,Liu ^[5]

作者单位： School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan 250117, PR China. ^[1] Department of Clinical Pharmacy, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, Shandong Engineering and Technology Research Center for Pediatric Drug Development; Shandong Medicine and Health Key Laboratory of Clinical Pharmacy, Ji'nan 250014, PR China. ^[2] Department of Environmental Health, University of Fukui School of Medical Sciences, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui 910-1193, Japan. ^[3] Department of Medicinal Chemistry, Key Laboratory of Chemical Biology, Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Shandong Province, Ji'nan 250012, PR China. ^[4] School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences, Ji'nan 250117, PR China. Electronic address: liubo@sdfmu.edu.cn. ^[5]

关键词 Anti-prostatic cancer S1P SphK inhibitors Structure activity relationship Structure-based drug design Virtual screening