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Electroporation and LNP-mediated delivery of plasmid DNA-encoded H5N1 influenza virus hemagglutinin support protection against highly pathogenic avian influenza.

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第一作者： Ebony N,Gary

第一单位： The Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.

作者： Ebony N,Gary ^[1] ; Nicholas J,Tursi ^[2] ; Casey E,Hojecki ^[1] ; Robert,Vendramelli ^[3] ; Martina,Tomirotti ^[4] ; Bryce,Warner ^[3] ; Cory,Livingston ^[1] ; Thang,Truong ^[3] ; Yangcheng,Gao ^[5] ; Sachchidanand,Tiwari ^[6] ; Norbert,Pardi ^[6] ; Darwyn,Kobasa ^[3] ; David B,Weiner ^[7]

作者单位： The Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA. ^[1] The Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.;The Perelman school of medicine, The University of Pennsylvania, Philadelphia, PA, USA. ^[2] National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB, Canada. ^[3] The Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.;The Department of Pharmacy and Biotechnology, The University of Bologna, Bologna, Italy. ^[4] The Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA.;The Graduate School of Biomedical Engineering, The University of Pennsylvania, Philadelphia, PA, USA. ^[5] Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[6] The Vaccine and Immunotherapy Center, The Wistar Institute, Philadelphia, PA, USA. dweiner@wistar.org. ^[7]

DOI 10.1038/s41541-025-01316-5

PMID 41274914

发布时间 2025-12-26

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Electroporation and LNP-mediated delivery of plasmid DNA-encoded H5N1 influenza virus hemagglutinin support protection against highly pathogenic avian influenza.

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Electroporation and LNP-mediated delivery of plasmid DNA-encoded H5N1 influenza virus hemagglutinin support protection against highly pathogenic avian influenza.

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