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Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activation.

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第一作者： Samuel J,Reisman

第一单位： Department of Cell Biology, Duke University, Durham, NC, USA.;Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.

作者： Samuel J,Reisman ^[1] ; Dahlia,Halabi ^[2] ; Samantha E,Miller ^[2] ; Lingyun,Song ^[3] ; Sara,Geraghty ^[4] ; Nicholas,Sangvai ^[5] ; Grayson,Rice ^[6] ; Alexias,Safi ^[3] ; Gregory E,Crawford ^[3] ; Charles A,Gersbach ^[7]

作者单位： Department of Cell Biology, Duke University, Durham, NC, USA.;Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA. ^[1] Department of Biomedical Engineering, Duke University, Durham, NC, USA. ^[2] Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.;Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. ^[3] Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA. ^[4] Department of Biology, Duke University, Durham, NC, USA. ^[5] Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.;Department of Biomedical Engineering, Duke University, Durham, NC, USA. ^[6] Department of Cell Biology, Duke University, Durham, NC, USA.;Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.;Department of Biomedical Engineering, Duke University, Durham, NC, USA. ^[7]

DOI 10.1101/2025.10.11.681828

PMID 41278743

发布时间 2025-11-27

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Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activation.

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Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activation.

bioRxiv

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