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Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate.

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第一作者： Roberta,Buono

第一单位： Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA.

作者： Roberta,Buono ^[1] ; Dennis,Juarez ^[1] ; Madhuri,Paul ^[1] ; Sarah J,Skuli ^[2] ; Ian B,Wong ^[1] ; Ishita,Tarnekar ^[1] ; Zhili,Ying ^[1] ; Izabelle,Le ^[3] ; Gerald,Wertheim ^[2] ; A'ishah,Bakayoko ^[2] ; Marisa,Kruidenier ^[2] ; Said M,Sebti ^[4] ; Marina,Konopleva ^[5] ; Angela G,Fleischman ^[6] ; Cholsoon,Jang ^[3] ; Martin,Carroll ^[2] ; David A,Fruman ^[1]

作者单位： Department of Molecular Biology & Biochemistry, University of California Irvine, Irvine, CA, 92697, USA. ^[1] Department of Medicine, Division of Hematology & Oncology, University of Pennsylvania, Philadelphia, PA 19104, USA. ^[2] Department of Biological Chemistry, Center for Epigenetics and Metabolism, Department of Chemistry, University of California Irvine, Irvine, CA, 92697, USA. ^[3] Department of Pharmacology and Toxicology and Massey Comprehensive Cancer Center, Virginia Commonwealth University, Richmond, VA, 23298, USA. ^[4] Albert Einstein Colege of Medicine, Montefiore Einstein Comprehensive Cancer Center, 1300 Morris Park Ave, Bronx, NY, 10461, USA. ^[5] Division of Hematology-Oncology, Department of Medicine, University of California Irvine, Irvine, CA, 92697, USA. ^[6]

DOI 10.1101/2025.10.27.684888

PMID 41280002

发布时间 2025-12-15

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Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate.

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Pitavastatin counteracts venetoclax resistance mechanisms in acute myeloid leukemia by depleting geranylgeranyl pyrophosphate.

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