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A bioluminescence-based chemical screen identifies a bactericidal naphthalene scaffold targeting MmpL3 in <i>Mycobacterium abscessus</i>.

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第一作者: Samsher,Singh
第一单位: Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.
作者单位: Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore. [1] Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore. [2] Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA. [3] Centre National de la Recherche Scientifique UMR 9004, Institut de Recherche en Infectiologie de Montpellier (IRIM), Université de Montpellier, Montpellier, France.;INSERM, IRIM, Montpellier, France. [4] Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.;Interdisciplinary Graduate Programme, Nanyang Technological University, Singapore. [5] Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, 637551, Singapore. [6] A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #05-13, Singapore 138648, Singapore. [7] Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.;A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), 8A Biomedical Grove, Immunos #05-13, Singapore 138648, Singapore. [8] Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland. [9] Department of Chemistry, National University of Singapore, Singapore, 117543, Singapore.;Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, 637551, Singapore. [10] Department of Microbiology and Immunology, Albert Einstein College of Medicine, New York, NY, USA.;Department of Public and Global Health, EBPI, University of Zurich, Zurich, Switzerland. [11] Department of Chemistry and Biochemistry, Montana State University, Bozeman, Montana, USA. [12] Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 636921, Singapore.;Singapore Centre for Environmental Life Sciences Engineering, Nanyang Technological University, Singapore, 637551, Singapore.;National Centre for Infectious Diseases, Singapore.;A*STAR Infectious Diseases Labs (A*STAR ID Labs), Agency for Science, Technology and Research (A*STAR), Singapore.;Lead contact. [13]
DOI 10.1101/2025.10.26.684512
PMID 41280111
发布时间 2025-12-01
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