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Polynitrogen-containing compounds as multi-target sEH/FAAH inhibitors: Structure-activity relationship and pharmacological studies.

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第一作者： Amanda,Tsang

第一单位： Department of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States.

作者： Amanda,Tsang ^[1] ; Cassandra,Yuan ^[1] ; Manuel,Berumen ^[1] ; Leah,Duong ^[1] ; Karen,Gomez ^[1] ; Shelby,Seely ^[1] ; Alex,Salgado ^[1] ; Adim,Rai ^[2] ; Jo,Vistosa ^[2] ; Edith Morales,Munoz ^[2] ; Marcos E,Ortega ^[3] ; Christophe,Morisseau ^[4] ; Bruce D,Hammock ^[4] ; Jake E,Zuckerman ^[5] ; Joseph,Yount ^[5] ; Davin G,Piercey ^[5] ; Ram,Kandasamy ^[6] ; Stevan,Pecic ^[7]

作者单位： Department of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States. ^[1] Department of Psychology, California State University, East Bay, 25800 Carlos Bee Blvd. Science S229, Hayward, CA 94542, United States. ^[2] Woody L. Hunt School of Dental Medicine, Texas Tech University Health Sciences Center, El Paso, 130 Rick Francis St., El Paso, TX 79905, United States. ^[3] Department of Entomology and Nematology, and UCD Comprehensive Cancer Center, University of California Davis, Davis, CA 95616, United States. ^[4] School of Materials Engineering and School of Mechanical Engineering, Purdue University, 585 Purdue Mall, West Lafayette, IN 47907, United States. ^[5] Department of Psychology, California State University, East Bay, 25800 Carlos Bee Blvd. Science S229, Hayward, CA 94542, United States. Electronic address: ram.kandasamy@csueastbay.edu. ^[6] Department of Chemistry & Biochemistry, California State University, Fullerton, 800 N. State College, Fullerton, CA 92834, United States. Electronic address: specic@fullerton.edu. ^[7]

关键词 Enzyme inhibition High?nitrogen drugs Microsome liver assay Microwave-assisted synthesis Multi-target directed ligands Structure-activity relationship Wheel running