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Metabolic reprogramming and altered ATP content impair neuroprotective functions of microglia in β-glucocerebrosidase deficiency models.

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第一作者： Electra,Brunialti

第一单位： Department of Health Sciences, University of Milan, Via di Rudinì 8, Milan, 20142, Italy.

作者： Electra,Brunialti ^[1] ; Alessandro,Villa ^[1] ; Eva M,Szego ^[2] ; Pietro,La Vitola ^[2] ; Denise,Drago ^[3] ; Radmila,Pavlovic ^[3] ; Laura,Fontana ^[4] ; Doga,Tuna ^[1] ; Alessia,Panzeri ^[1] ; Clara,Meda ^[1] ; Christin,Weissleder ^[5] ; Ornella,Rondinone ^[6] ; Mattia,Pitasi ^[7] ; Monica,Miozzo ^[4] ; Michela,Deleidi ^[5] ; Annapaola,Andolfo ^[3] ; Donato A,Di Monte ^[2] ; Paolo,Ciana ^[8]

作者单位： Department of Health Sciences, University of Milan, Via di Rudinì 8, Milan, 20142, Italy. ^[1] German Center for Neurodegenerative Diseases (DZNE), Venusberg- Campus 1, Gebäude 99, Bonn, 53127, Germany. ^[2] Center for Omics Sciences (COSR), IRCCS San Raffaele Scientific Institute, Via Olgettina 60, Milan, 20132, Italy. ^[3] Medical Genetics, Department of Health Sciences, University of Milan, Via di Rudinì 8, Milan, 20142, Italy.;Medical Genetic Unit, ASST Santi Paolo e Carlo, Via di Rudinì 8, Milan, 20142, Italy. ^[4] Mechanisms and Therapy of Genetic Brain Diseases, Institut Imagine, INSERM UMR1163, 24 Bd du Montparnasse, Paris, 75015, France. ^[5] Medical Genetics, Department of Health Sciences, University of Milan, Via di Rudinì 8, Milan, 20142, Italy. ^[6] Department of Microbiology, Immunobiology and Genetics, Max Perutz Labs, University of Vienna, Dr. Bohr-Gasse 9, Vienna, A-1030, Austria. ^[7] Department of Health Sciences, University of Milan, Via di Rudinì 8, Milan, 20142, Italy. paolo.ciana@unimi.it. ^[8]

关键词 ATP Energetic failure Gaucher’s disease Microglia Neuroprotection Parkinson’s disease

DOI 10.1186/s12974-025-03616-y

PMID 41291747

发布时间 2025-11-28

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