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Design, Synthesis, and Biological Evaluation of 5',7-Disubstituted 7-Deaza-adenosine Analogues as Irreversible Pan-FGFR Inhibitors.

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第一作者： Jung Hoon,Park

第一单位： Republic of Korea Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.

作者： Jung Hoon,Park ^[1] ; Phuong Thao,Tran ^[1] ; Hye Lin,Ko ^[2] ; Seonghee,Mun ^[2] ; Sung Chul,Jang ^[1] ; Dong Hyun,Moon ^[1] ; Jaeho,Han ^[1] ; Jieun,Kim ^[1] ; Gibae,Kim ^[1] ; Hongseok,Choi ^[1] ; Seung Woo,Kim ^[1] ; Minjae,Kim ^[1] ; Sang Kook,Lee ^[1] ; Byung Woo,Han ^[2] ; Keon Wook,Kang ^[1] ; Lak Shin,Jeong ^[3]

作者单位： Republic of Korea Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. ^[1] Republic of Korea Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.;2 Research Institute of Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea. ^[2] Republic of Korea Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.;Future Medicine Co., Ltd., 54 Changup-ro, Sujeong-gu, Seongnam 13449, Republic of Korea. ^[3]

关键词 X-ray crystallography covalent inhibitors metabolic stability molecular dynamics simulations nucleoside analogues pan-FGFR inhibitors

DOI 10.3390/ph18111745

PMID 41304987

发布时间 2025-11-30

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