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Hyperthermia-induced BRCA2 reduction potentiates PARPi sensitivity in BRCA2-proficient ovarian carcinoma.

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第一作者： Bingjie,Mei

第一单位： Department Gynecological Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

作者： Bingjie,Mei ^[1] ; Junyang,Li ^[2] ; Xiaoyu,Hou ^[2] ; Jie,Zhang ^[2] ; Dengfeng,Wang ^[3] ; Jianming,Huang ^[4] ; Guonan,Zhang ^[5]

作者单位： Department Gynecological Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. ^[1] Department Gynecological Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. ^[2] Department Gynecological Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. wonderful_96@163.com. ^[3] Department of Biochemistry and Molecular Biology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. wesleyhuangcn2002@163.com. ^[4] Department Gynecological Oncology, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China. zhanggn@hotmail.com. ^[5]

关键词 BRCA2 Homologous recombination Hyperthermia Ovarian cancer PARP inhibition

DOI 10.1007/s12672-025-03898-x

PMID 41310299

发布时间 2026-01-01

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Hyperthermia-induced BRCA2 reduction potentiates PARPi sensitivity in BRCA2-proficient ovarian carcinoma.

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Hyperthermia-induced BRCA2 reduction potentiates PARPi sensitivity in BRCA2-proficient ovarian carcinoma.

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