首页> European journal of medicinal chemistry> Discovery of novel harmine derivatives as potent, selective, and brain permeable GSK3β inhibitors with effective In vivo anti-AD activity.

Discovery of novel harmine derivatives as potent, selective, and brain permeable GSK3β inhibitors with effective In vivo anti-AD activity.

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第一作者： Wenjie,Liu

第一单位： College of Life and Health Sciences, Northeastern University, Shenyang, 110819, PR China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110000, PR China.

作者： Wenjie,Liu ^[1] ; Limeng,Wu ^[2] ; Xi,Zeng ^[3] ; Huanhua,Chen ^[4] ; Xinyue,Ning ^[5] ; Xiaoyu,Sun ^[6] ; Wenqiang,Xuan ^[6] ; Ying,Hao ^[6] ; Hongli,Jia ^[7] ; Zhenshu,Li ^[4] ; Zonghe,Xu ^[4] ; Xinyu,Li ^[4] ; Zihua,Xu ^[8] ; Wenwu,Liu ^[9] ; Qingchun,Zhao ^[10] ; Shuang,Hao ^[11]

作者单位： College of Life and Health Sciences, Northeastern University, Shenyang, 110819, PR China; Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110000, PR China. ^[1] Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110000, PR China; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. ^[2] Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110000, PR China; National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Army Medical University, Chongqing, 400038, PR China. ^[3] Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110000, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. ^[4] Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110000, PR China; Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. ^[5] College of Life and Health Sciences, Northeastern University, Shenyang, 110819, PR China. ^[6] State Key Laboratory of Natural and Biomimetic Drugs, Chemical Biology Center, School of Pharmaceutical Sciences, Peking University, Beijing, 100191, PR China. ^[7] Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110000, PR China. ^[8] Department of Pharmacy, Peking University First Hospital, Beijing, 100034, PR China. Electronic address: sunny961010@163.com. ^[9] Department of Pharmacy, General Hospital of Northern Theater Command, Shenyang, 110000, PR China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, 110016, PR China; Department of Clinical Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, PR China. Electronic address: zhaoqingchun1967@163.com. ^[10] College of Life and Health Sciences, Northeastern University, Shenyang, 110819, PR China. Electronic address: haoshuang@mail.neu.edu.cn. ^[11]

关键词 Alzheimer's disease Blood-brain barrier permeability GSK3β Harmine Tau phosphorylation β-Carboline