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Advancing automated cell type annotation with large language models and single-cell isoform sequencing.

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第一作者： Hettiarachchige,Wijewardena

第一单位： Computational Biomedicine Lab, College of Science and Engineering, James Cook University, Townsville, QLD, Australia.

作者： Hettiarachchige,Wijewardena ^[1] ; Saloni,Bhatia ^[1] ; Namrata,Bhattacharya ^[2] ; Debarka,Sengupta ^[3] ; Siyuan,Wu ^[4] ; Ulf,Schmitz ^[5]

作者单位： Computational Biomedicine Lab, College of Science and Engineering, James Cook University, Townsville, QLD, Australia. ^[1] Australian Prostate Cancer Research Centre-Queensland, Faculty of Health, School of Biomedical Sciences, Centre for Genomics and Personalised Health, Queensland University of Technology, Brisbane, QLD 4000, Australia.;Department of Computer Science and Engineering, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), Okhla, Phase III, New Delhi 110020, India.;Translational Research Institute, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia. ^[2] Department of Computer Science and Engineering, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), Okhla, Phase III, New Delhi 110020, India.;Department of Computational Biology, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), Okhla, Phase III, New Delhi 110020, India.;Centre for Artificial Intelligence, Indraprastha Institute of Information Technology-Delhi (IIIT-Delhi), Okhla, Phase III, New Delhi 110020, India. ^[3] Computational Biomedicine Lab, College of Science and Engineering, James Cook University, Townsville, QLD, Australia.;School of Mathematics, Monash University, Melbourne, Victoria 3800, Australia.;Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia. ^[4] Computational Biomedicine Lab, College of Science and Engineering, James Cook University, Townsville, QLD, Australia.;Centre for Tropical Bioinformatics and Molecular Biology, Australian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.;Centenary Institute, The University of Sydney, Camperdown, Australia. ^[5]

关键词 Alternative splicing Automatic cell type annotation Large language models Machine learning Natural language processing Single-cell RNA sequencing Transcript isoforms

DOI 10.1016/j.csbj.2025.11.008

PMID 41322002

发布时间 2025-12-03

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