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Genome-wide gene-sleep interaction study identifies novel lipid loci in 732,564 participants.

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第一作者: Raymond,Noordam
第一单位: Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Health Campus the Hague/Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: r.noordam@lumc.nl.
作者: Raymond,Noordam [1] ; Wenyi,Wang [2] ; Pavithra,Nagarajan [3] ; Heming,Wang [4] ; Michael R,Brown [5] ; Amy R,Bentley [6] ; Qin,Hui [7] ; Aldi T,Kraja [8] ; John L,Morrison [9] ; Jeffrey R,O'Connel [10] ; Songmi,Lee [11] ; Karen,Schwander [12] ; Traci M,Bartz [13] ; Lisa,de Las Fuentes [14] ; Mary F,Feitosa [15] ; Xiuqing,Guo [16] ; Xu,Hanfei [17] ; Sarah E,Harris [18] ; Zhijie,Huang [19] ; Mart,Kals [20] ; Christophe,Lefevre [21] ; Massimo,Mangino [22] ; Yuri,Milaneschi [23] ; Peter J,van der Most [24] ; Natasha L,Pacheco [25] ; Nicholette D,Palmer [26] ; Varun,Rao [27] ; Rainer,Rauramaa [28] ; Quan,Sun [29] ; Yasuharu,Tabara [30] ; Dina,Vojinovic [31] ; Yujie,Wang [32] ; Stefan,Weiss [33] ; Qian,Yang [34] ; Wei,Zhao [35] ; Wanying,Zhu [36] ; Md Abu Yusuf,Ansari [37] ; Hugues,Aschard [38] ; Pramod,Anugu [39] ; Themistocles L,Assimes [40] ; John,Attia [41] ; Laura D,Baker [42] ; Christie,Ballantyne [43] ; Lydia,Bazzano [19] ; Eric,Boerwinkle [44] ; Brain,Cade [4] ; Hung-Hsin,Chen [36] ; Wei,Chen [19] ; Yii-Der,Ida Chen [17] ; Zekai,Chen [24] ; Kelly,Cho [45] ; Ileana,De Anda-Duran [19] ; Latchezar,Dimitrov [26] ; Anh,Do [46] ; Todd,Edwards [47] ; Tariq,Faquih [4] ; Aroon,Hingorani [48] ; Susan P,Fisher-Hoch [49] ; J Michael,Gaziano [45] ; Sina A,Gharib [50] ; Ayush,Giri [51] ; Mohsen,Ghanbari [31] ; Hans Jörgen,Grabe [52] ; Mariaelisa,Graff [32] ; C,Charles Gu [46] ; Jiang,He [19] ; Sami,Heikkinen [53] ; James,Hixson [54] ; Yuk-Lam,Ho [55] ; Michelle M,Hood [56] ; Serena C,Houghton [55] ; Carrie A,Karvonen-Gutierrez [56] ; Takahisa,Kawaguchi [57] ; Tuomas O,Kilpeläinen [58] ; Pirjo,Komulainen [28] ; Henry J,Lin [16] ; Gregorio V,Linchangco [59] ; Annemarie I,Luik [31] ; Jintao,Ma [60] ; James B,Meigs [61] ; Joseph B,McCormick [49] ; Cristina,Menni [22] ; Ilja M,Nolte [24] ; Jill M,Norris [62] ; Lauren E,Petty [36] ; Hannah G,Polikowsky [36] ; Laura M,Raffield [63] ; Stephen S,Rich [64] ; Renata L,Riha [65] ; Thomas C,Russ [66] ; Edward A,Ruiz-Narvaez [67] ; Colleen M,Sitlani [68] ; Jennifer A,Smith [35] ; Harold,Snieder [24] ; Tamar,Sofer [69] ; Botong,Shen [25] ; Jingxian,Tang [17] ; Kent D,Taylor [70] ; Maris,Teder-Laving [20] ; Rima,Triatin [71] ; Michael Y,Tsai [72] ; Henry,Völzke [73] ; Kenneth E,Westerman [74] ; Rui,Xia [11] ; Jie,Yao [16] ; Kristin L,Young [32] ; Ruiyuan,Zhang [19] ; Alan B,Zonderman [25] ; Xiaofeng,Zhu [75] ; Jennifer E,Below [36] ; Simon R,Cox [18] ; Michelle,Evans [25] ; Myriam,Fornage [76] ; Ervin R,Fox [77] ; Nora,Franceschini [78] ; Sioban D,Harlow [56] ; Elizabeth,Holliday [41] ; M Arfan,Ikram [31] ; Tanika,Kelly [27] ; Timo A,Lakka [79] ; Deborah A,Lawlor [34] ; Changwei,Li [12] ; Ching-Ti,Liu [19] ; Reedik,Mägi [20] ; Alisa K,Manning [80] ; Fumihiko,Matsuda [57] ; Alanna C,Morrison [5] ; Matthias,Nauck [81] ; Kari E,North [32] ; Brenda Wjh,Penninx [23] ; Michael A,Province [12] ; Bruce M,Psaty [82] ; Jerome I,Rotter [16] ; Tim D,Spector [83] ; Lynne E,Wagenknecht [84] ; Ko Willems,van Dijk [85] ; Lifelines Cohort Study [86] ; Million Veteran Program [87] ; Cashell E,Jaquish [59] ; Peter Wf,Wilson [56] ; Patricia A,Peyser [88] ; Patricia B,Munroe [5] ; Paul S,de Vries [9] ; W James,Gauderman [59] ; Yan V,Sun [5] ; Han,Chen [89] ; Clint L,Miller [90] ; Thomas W,Winkler [46] ; Dabeeru C,Rao [4] ; Susan,Redline [91] ; Diana,van Heemst
作者单位: Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands; Health Campus the Hague/Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: r.noordam@lumc.nl. [1] Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands. [2] Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA. [3] Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; Division of Sleep Medicine, Harvard Medical School, Boston, MA, USA. [4] Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. [5] Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. [6] Rollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA. [7] University of Mississippi Medical Center, Jackson, MS, USA. [8] Divison of Biostatistics and Health Data Science, Department of Population and Public Health Sciences, University of Southern California, Los Angeles, CA, USA. [9] Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. [10] Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA. [11] Division of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA. [12] Cardiovascular Health Research Unit, Department of Biostatistics and Medicine, University of Washington, Seattle, WA, USA. [13] Center for Biostatistics and Data Science, Institute for Informatics, Data Science and Biostatistics, Washington University in St. Louis, St. Louis, Missouri, USA; Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA. [14] Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA. [15] The Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. [16] Department of Biostatistics, Boston University, Boston, MA, USA. [17] Lothian Birth Cohorts, Department of Psychology, The University of Edinburgh, Edinburgh, UK. [18] Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA. [19] Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, Estonia. [20] Department of Bioinformatics, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. [21] Department of Twin Research, King's College London, London, UK. [22] GGZ inGeest, Amsterdam, the Netherlands; Department of Psychiatry, Amsterdam UMC/Vrije universiteit, Amsterdam, the Netherlands. [23] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [24] National Institute on Aging, Laboratory of Epidemiology and Population Sciences, National Institutes of Health, Baltimore, MD, USA. [25] Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC, USA. [26] Division of Nephrology, Department of Medicine, University of Illinois Chicago, Chicago, IL, USA. [27] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. [28] Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [29] Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan; Graduate School of Public Health, Shizuoka Graduate University of Public Health, Shizuoka, Japan. [30] Department of Epidemiology, Erasmus MC University Medical Center, Rotterdam, the Netherlands. [31] Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC, USA. [32] Department of Functional Genomics, Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany; DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greiswald, Germany. [33] MRC Integrative Epidemiology Unit at then University of Bristol, Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK. [34] Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA. [35] Division of Genetic Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. [36] Department of Data Science, University of Mississippi Medical Center, Jackson, MS, USA. [37] Institut Pasteur, Université Paris Cité, Department of Computational Biology, F-75015 Paris, France; Department of Epidemiology, Harvard TH School of Public Health, Boston, MA, 2115, USA. [38] Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA. [39] Division of Cardiology, Department of Medicine, Palo Alto VA Healthcare System, Palo Alta, CA, USA; Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA, USA. [40] School of Medicine and Public Health, University of Newcastle, New Lambton Heights, Australia. [41] Department of Internal Medicine (Geriatrics & Gerontology), Wake Forest University School of Medicine, Winston-Salem, NC, USA. [42] Department of Medicine, Baylor College of Medicine, Houston, TX, USA. [43] Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. [44] Division of Aging, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA. [45] Center for Biostatistics and Data Science, Institute for Informatics, Data Science, and Biostatistics, Washington University in St. Louis, School of Medicine, St. Louis, MO, 63110, USA. [46] Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37203, USA. [47] Faculty of Population Health, Institute of Cardiovascular Science, University College London, London, WC1E 6BT, UK. [48] School of Public Health, The University of Texas Health Science Center at Houston (UTHealth), Brownsville, TX, USA. [49] Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, University of Washington, Seattle, WA, USA. [50] Division of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, 37203, USA; Division of Quantitative Sciences, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, TN, USA. [51] Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany; German Centre for Neurodegenerative Diseases, Site Rostock/Greifswald, Greifswald, Germany. [52] Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland. [53] Department of Epidemiology, UTHealth School of Public Health, Houston TX, USA. [54] Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), Veterans Affairs Boston Healthcare System, Boston, MA, USA. [55] Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. [56] Center for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. [57] Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, 2142, USA. [58] Rollins School of Public Health, Department of Epidemiology, Emory University, Atlanta, GA, USA; Veterans Affairs Atlanta Healthcare System, Decatur, GA, USA. [59] Nutrition Epidemiology and Data Science, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, 2111, USA. [60] Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Division of General Internal Medicine, Massachusetts General Hospital, 100 Cambridge St 16th Floor, Boston, MA, USA. [61] Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, USA. [62] Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. [63] Center for Public Health Genomics, University of Virginia, Charlottesville, VA, USA; Department of Public Health Sciences, University of Virginia, Charlottesville, VA, USA. [64] Department of Sleep Medicine, The University of Edinburgh, Edinburgh, UK. [65] Alzheimer Scotland, Dementia Research Centre, The University of Edinburgh, Edinburgh, UK; Division of Psychiatry, Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK. [66] Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA. [67] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. [68] Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA; CardioVascular Institute (CVI), Beth Israel Deaconness Medical Center, Boston, MA, USA. [69] Division of Genomic Outcomes, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA, USA. [70] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Biomedical Sciences, Universitas Padjadjaran, Bandung, Indonesia. [71] Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA. [72] DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greiswald, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. [73] Programs in Metabolism and Medical & Population Genetics, The Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Medicine, Harvard Medical School, Boston, MA, USA; Department of Medicine, Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital, Boston, MA, USA. [74] Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA. [75] Department of Epidemiology, University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA; Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX, USA. [76] Department of Medicine, University of Mississippi Medical Center, Jackson, MS, USA. [77] Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. [78] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland; Institute of Biomedicine, School of Medicine, University of Eastern Finland, Kuopio, Finland; Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. [79] Massachusetts General Hospital, Clinical and Translational Epidemiology Unit, Department of Medicine, Boston, MA, 02114, USA; Metabolism Program, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. [80] DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greiswald, Germany; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. [81] Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA; Department of Epidemiology, University of Washington, Seattle, WA, USA. [82] GGZ inGeest, Amsterdam, the Netherlands. [83] Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. [84] Department of Human Genetics, Leiden University Medical Center, Leiden, the Netherlands; Department of Internal Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, the Netherlands. [85] Roden, the Netherlands. [86] Division of Cardiovascular Science, Epidemiology Branch, NHLBI, NIH, Bethesda, MD, 20817, USA. [87] William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK; National Institute of Health and Care Research Barts Biomedical Research Centre, Queen Mary University of London, London, UK. [88] Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA, 22908, USA; Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, VA, 22908, USA. [89] Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. [90] Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands. [91]
DOI 10.1016/j.atherosclerosis.2025.120603
PMID 41325697
发布时间 2026-04-08
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