换一批Ceftriaxone alleviates mitochondrial damage through the inhibition of extrasynaptic NMDA receptor-mediated changes in intracellular calcium levels to improve cognitive deficits in APP/PS1 mice.
第一作者：
Li-Rong,Liu
第一单位：
Department of Pathophysiology, Neuroscience Research Center, Hebei Key Laboratory of Critical Disease Mechanism and Intervention, Hebei Medical University, 361 Zhongshan East Road, Shijiazhuang, 050017, P. R. China.
作者：
医学主题词
动物(Animals);头孢曲松(Ceftriaxone);线粒体(Mitochondria);小鼠(Mice);钙(Calcium);受体, N-甲基-D-天冬氨酸(Receptors, N-Methyl-D-Aspartate);小鼠, 转基因(Mice, Transgenic);小鼠, 近交C57BL(Mice, Inbred C57BL);早老素1(Presenilin-1);男(雄)性(Male);淀粉样β蛋白前体(Amyloid beta-Protein Precursor);疾病模型, 动物(Disease Models, Animal);阿尔茨海默病(Alzheimer Disease);海马(Hippocampus);兴奋性氨基酸转运子2(Excitatory Amino Acid Transporter 2)
DOI
10.1186/s13195-025-01900-w
PMID
41327376
发布时间
2026-05-14
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