首页> International journal of biological macromolecules> Unveiling the effect of phosphorylation and phosphomimetics on the structural and aggregation properties of the amyloidogenic intrinsically disordered protein DPF3a.

Unveiling the effect of phosphorylation and phosphomimetics on the structural and aggregation properties of the amyloidogenic intrinsically disordered protein DPF3a.

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第一作者： Tanguy,Leyder

第一单位： Laboratoire de Chimie Physique des Biomolécules, UCPTS, University of Namur, 5000, Namur, Belgium; Namur Institute of Structured Matter (NISM), University of Namur, 5000, Namur, Belgium; Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000, Namur, Belgium. Electronic address: tanguy.leyder@unamur.be.

作者： Tanguy,Leyder ^[1] ; Julien,Mignon ^[2] ; Emma,Bongiovanni ^[3] ; Quentin,Machiels ^[4] ; Jehan,Waeytens ^[5] ; Vincent,Raussens ^[6] ; Antonio,Monari ^[7] ; Denis,Mottet ^[8] ; Catherine,Michaux ^[9]

作者单位： Laboratoire de Chimie Physique des Biomolécules, UCPTS, University of Namur, 5000, Namur, Belgium; Namur Institute of Structured Matter (NISM), University of Namur, 5000, Namur, Belgium; Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000, Namur, Belgium. Electronic address: tanguy.leyder@unamur.be. ^[1] Laboratoire de Chimie Physique des Biomolécules, UCPTS, University of Namur, 5000, Namur, Belgium; Namur Institute of Structured Matter (NISM), University of Namur, 5000, Namur, Belgium; Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000, Namur, Belgium. Electronic address: julien.mignon@unamur.be. ^[2] Laboratoire de Chimie Physique des Biomolécules, UCPTS, University of Namur, 5000, Namur, Belgium. Electronic address: emma.bongiovanni@student.unamur.be. ^[3] Laboratoire de Structure et Fonction des Membranes Biologiques, Université Libre de Bruxelles, 1050 Bruxelles, Belgium; RD3-Pharmacognosy, Bioanalysis and Drug Discovery Unit, Faculty of Pharmacy, Université Libre de Bruxelles, 1050 Bruxelles, Belgium. Electronic address: quentin.machiels@ulb.be. ^[4] RD3-Pharmacognosy, Bioanalysis and Drug Discovery Unit, Faculty of Pharmacy, Université Libre de Bruxelles, 1050 Bruxelles, Belgium. Electronic address: jehan.waeytens@ulb.be. ^[5] Laboratoire de Structure et Fonction des Membranes Biologiques, Université Libre de Bruxelles, 1050 Bruxelles, Belgium. Electronic address: vincent.raussens@ulb.be. ^[6] Université Paris Cité and CNRS, ITODYS, 75006, Paris, France. Electronic address: antonio.monari@u-paris.fr. ^[7] Gene Expression and Cancer Laboratory, GIGA-Molecular Biology of Diseases, University of Liège, 4000, Liège, Belgium. Electronic address: dmottet@uliege.be. ^[8] Laboratoire de Chimie Physique des Biomolécules, UCPTS, University of Namur, 5000, Namur, Belgium; Namur Institute of Structured Matter (NISM), University of Namur, 5000, Namur, Belgium; Namur Research Institute for Life Sciences (NARILIS), University of Namur, 5000, Namur, Belgium. Electronic address: catherine.michaux@unamur.be. ^[9]

关键词 Amyloidogenic protein Autofluorescence Double PHD fingers 3a (DPF3a)Intrinsically disordered protein Microscopy Molecular dynamics Phosphorylation Spectroscopy

医学主题词磷酰化(Phosphorylation);人类(Humans);DNA结合蛋白质类(DNA-Binding Proteins);转录因子(Transcription Factors);酪蛋白激酶Ⅱ(Casein Kinase II);淀粉样蛋白(Amyloid);促淀粉样变蛋白质类(Amyloidogenic Proteins)

DOI 10.1016/j.ijbiomac.2025.149393

PMID 41330221

发布时间 2025-12-11

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