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High throughput identification of genetic regulators of microglial inflammatory processes in Alzheimer's disease.

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第一作者： Christopher L,Cardona

第一单位： Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY, USA.

作者： Christopher L,Cardona ^[1] ; Lai,Wei ^[2] ; Joonwon,Kim ^[3] ; Ellen,Angeles ^[4] ; Gunjandeep,Singh ^[4] ; Shiye,Chen ^[2] ; Ronak,Patel ^[4] ; Nkechime,Ifediora ^[1] ; Peter,Canoll ^[1] ; Andrew F,Teich ^[1] ; Gunnar,Hargus ^[1] ; Alejandro,Chavez ^[5] ; Andrew A,Sproul ^[6]

作者单位： Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY, USA. ^[1] Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. ^[2] Department of Pediatrics, University of California San Diego, La Jolla, CA, USA.;Department of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea. ^[3] Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Taub Institute), CUIMC, New York, NY, USA. ^[4] Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. chavez2@health.ucsd.edu. ^[5] Department of Pathology and Cell Biology, Columbia University Irving Medical Center (CUIMC), New York, NY, USA. aas2003@cumc.columbia.edu.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain (Taub Institute), CUIMC, New York, NY, USA. aas2003@cumc.columbia.edu. ^[6]

关键词 Alzheimer’s disease CRISPRi screen CROP-seq EED INPP5D Inflammation MS4A6A Microglia RABEP1 hiPSCs

DOI 10.1186/s12974-025-03562-9

PMID 41340152

发布时间 2026-04-30

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