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Interlaboratory clinical chemistry parameter variation in seven-day acute hydrazine toxicity studies in the Sprague-Dawley rat.

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第一作者： Janonna,Kadyrov

第一单位： Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA, Australia.

作者： Janonna,Kadyrov ^[1] ; Samuele,Sala ^[1] ; Lucy,Grigoroff ^[1] ; Reika,Masuda ^[1] ; Samantha,Lodge ^[1] ; Timothy M,Ebbels ^[2] ; Michael D,Reily ^[3] ; Donald,Robertson ^[3] ; Lois,Lehman-McKeeman ^[4] ; John,Shockcor ^[5] ; Bruce D,Car ^[4] ; Craig,Thomas ^[6] ; John C,Lindon ^[7] ; Julien,Wist ^[8] ; Jeremy K,Nicholson ^[9] ; Elaine,Holmes ^[10]

作者单位： Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA, Australia. ^[1] Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, Hammersmith Campus, London, W12 0NN, UK. ^[2] Formerly Pfizer Global R&D, Ann Arbor, MI, USA. ^[3] Formerly Bristol-Myers-Squibb Company, Princeton, NJ, USA. ^[4] Formerly Drug Metabolism and Pharmacokinetics Section, Stine-Haskell Research Center, Dupont Pharmaceuticals Company, Newark, DE, USA. ^[5] ThomaPharma Consulting LLC, McCordsville, IN, 46055, USA.;Formerly Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, 46055, USA. ^[6] Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK. ^[7] Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA, Australia. Julien.wist@murdoch.edu.au.;Institute of Global Health Innovation, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK. Julien.wist@murdoch.edu.au.;Chemistry Department, Universidad del Valle, Cali, 76001, Colombia. Julien.wist@murdoch.edu.au. ^[8] Institute of Global Health Innovation, Faculty of Medicine, Imperial College London, London, SW7 2AZ, UK. j.nicholson@imperial.ac.uk. ^[9] Centre for Computational and Systems Medicine, Health Futures Institute, Murdoch University, Perth, WA, Australia. elaine.holmes@imperial.ac.uk.;Department of Metabolism, Digestion and Reproduction, Faculty of Medicine, Imperial College London, London, UK. elaine.holmes@imperial.ac.uk. ^[10]

关键词 Clinical chemistry Hydrazine toxicity Multisite study Sprague-Dawley

医学主题词动物(Animals);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);肼类(Hydrazines);男(雄)性(Male);大鼠(Rats);实验室(Laboratories);临床化学试验(Clinical Chemistry Tests)

DOI 10.1007/s00204-025-04227-5

PMID 41350941

发布时间 2026-03-10

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